AIMC Topic: Rats

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De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework.

Journal of chemical information and modeling
Likely effective pharmacological interventions for the treatment of opioid addiction include attempts to attenuate brain reward deficits during periods of abstinence. Pharmacological blockade of the κ-opioid receptor (KOR) has been shown to abolish b...

Experimental validation of the free-energy principle with in vitro neural networks.

Nature communications
Empirical applications of the free-energy principle are not straightforward because they entail a commitment to a particular process theory, especially at the cellular and synaptic levels. Using a recently established reverse engineering technique, w...

A Weakly Supervised Deep Learning Framework for Whole Slide Classification to Facilitate Digital Pathology in Animal Study.

Chemical research in toxicology
The pathology of animal studies is crucial for toxicity evaluations and regulatory assessments, but the manual examination of slides by pathologists remains time-consuming and requires extensive training. One inherent challenge in this process is the...

Identifying the active ingredients of carbonized Typhae Pollen by spectrum-effect relationship combined with MBPLS, PLS, and SVM algorithms.

Journal of pharmaceutical and biomedical analysis
Typhae Pollen (TP) and its carbonized product (carbonized Typhae Pollen, CTP), as cut-and-dried herbal drugs, have been widely used in the form of slices in clinical settings. However, the two drugs exhibit a great difference in terms of their clinic...

Amplifying the Effects of Contrast Agents on Magnetic Resonance Images Using a Deep Learning Method Trained on Synthetic Data.

Investigative radiology
OBJECTIVES: Artificial intelligence (AI) methods can be applied to enhance contrast in diagnostic images beyond that attainable with the standard doses of contrast agents (CAs) normally used in the clinic, thus potentially increasing diagnostic power...

A deep-learning assisted bioluminescence tomography method to enable radiation targeting in rat glioblastoma.

Physics in medicine and biology
. A novel solution is required for accurate 3D bioluminescence tomography (BLT) based glioblastoma (GBM) targeting. The provided solution should be computationally efficient to support real-time treatment planning, thus reducing the x-ray imaging dos...

Bioinspired Soft Spine Enables Small-Scale Robotic Rat to Conquer Challenging Environments.

Soft robotics
For decades, it has been difficult for small-scale legged robots to conquer challenging environments. To solve this problem, we propose the introduction of a bioinspired soft spine into a small-scale legged robot. By capturing the motion mechanism of...

PMotion: an advanced markerless pose estimation approach based on novel deep learning framework used to reveal neurobehavior.

Journal of neural engineering
The evaluation of animals' motion behavior has played a vital role in neuromuscular biomedical research and clinical diagnostics, which reflects the changes caused by neuromodulation or neurodamage. Currently, the existing animal pose estimation meth...

Detrimental Effects of Saccharum officinarum Juice on Reproductive Functions of Female Wistar Rats.

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria
Changing dietary compositions have contributed to the growing epidemic of metabolic diseases with serious impacts on several aspects of health, including reproductive health.  Saccharum officinarum juice has a natural sweetness that makes the general...