AIMC Topic: Rats
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Deep learning for high-throughput quantification of oligodendrocyte ensheathment at single-cell resolution.
Communications biology
Mar 26, 2019
High-throughput quantification of oligodendrocyte myelination is a challenge that, if addressed, would facilitate the development of therapeutics to promote myelin protection and repair. Here, we established a high-throughput method to assess oligode...
The Effect of the Prethanol Extract of Trifolium pratense Leaves on Interleukin-1β-Induced Cartilage Matrix Degradation in Primary Rat Chondrocytes.
Cells, tissues, organs
Jan 31, 2019
BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease, characterized by cartilage degradation and inflammation. The proinflammatory cytokine, interleukin (IL)-1β, plays a crucial role in the pathogenesis of OA by inducing the release of oth...
Neuroprotective role of 6-Gingerol-rich fraction of Zingiber officinale (Ginger) against acrylonitrile-induced neurotoxicity in male Wistar rats.
Journal of basic and clinical physiology and pharmacology
Dec 22, 2018
Background Acrylonitrile (AN) is a neurotoxin that is widely used to manufacture synthetic fibres, plastics and beverage containers. Recently, we reported the ameliorative role of 6-gingerol-rich fraction from Zingiber officinale (Ginger, GRF) on the...
Rats
Fatty Alcohols
Inflammation
Tumor Necrosis Factor-alpha
Oxidative Stress
Nitric Oxide
Zingiber officinale
Antioxidants
Interleukin-6
Malondialdehyde
Neuroprotection
Plant Extracts
Animals
Glutathione Peroxidase
Glutathione Transferase
Superoxide Dismutase
Catalase
Glutathione
Male
Rats, Wistar
Lipid Peroxidation
Acrylonitrile
Catechols
Cerebral Cortex
Quantitative ultrasound and machine learning for assessment of steatohepatitis in a rat model.
European radiology
Dec 17, 2018
OBJECTIVES: To develop a machine learning model based on quantitative ultrasound (QUS) parameters to improve classification of steatohepatitis with shear wave elastography in rats by using histopathology scoring as the reference standard.
Effect of Wuziyanzong pill on metabolism of dapoxetine in vivo and in vitro.
Journal of pharmaceutical and biomedical analysis
Dec 15, 2018
In vitro incubation of rat liver microsomes with 30 μL of 100 μmol·L dapoxetine and 30 μL of 10, 100, 250, 500, 1000, 2500, or 5000 μg·mL Wuziyanzong pill was performed at 37 °C for 60 min. Dapoxetine concentration was analyzed by high performance li...
Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-B/p65 Signaling in Chronic Radiculitis Rats.
Pain research & management
Dec 13, 2018
BACKGROUND: Oxygen/ozone therapy is a minimally invasive technique for the treatment of radiculitis from lumbar disc herniation. This study aimed at investigating whether intrathecal administration of low-concentration oxygen/ozone could attenuate ch...
Seasonal Variation in Essential Oils Composition and the Biological and Pharmaceutical Protective Effects of Leaves Grown in Tunisia.
BioMed research international
Dec 9, 2018
This research assessed the seasonal variation of the chemical composition and antibacterial and anticholinesterase activities of essential oils extracted from leaves. The leaves organic fractions were also investigated for their biological activitie...
Novel indolizine derivatives lowers blood glucose levels in streptozotocin-induced diabetic rats: A histopathological approach.
Pharmacological reports : PR
Nov 28, 2018
BACKGROUND: Diabetes mellitus is a deadly disorder in human which induce chronic complications. The streptozotocin (STZ)-induced diabetes in rat is the most common animal model of human diabetes. The present study investigated the effects of novel in...
Ontology-based semantic mapping of chemical toxicities.
Toxicology
Nov 20, 2018
This study was undertaken to evaluate the use of ontology-based semantic mapping (OS-Mapping) in chemical toxicity assessment. Nineteen chemical-species phenotypic profiles (CSPPs) were constructed by ontologically annotating the toxicity responses r...
Metabolomics predicts the pharmacological profile of new psychoactive substances.
Journal of psychopharmacology (Oxford, England)
Nov 19, 2018
BACKGROUND: The unprecedented proliferation of new psychoactive substances (NPS) threatens public health and challenges drug policy. Information on NPS pharmacology and toxicity is, in most cases, unavailable or very limited and, given the large numb...
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