OBJECTIVE: This study aimed to investigate the feasibility and potential value of predictive models for human epidermal growth factor receptor 2 (HER2)-positive status in breast cancer (BC) based on radiomics features from conventional ultrasound ima...
Small extracellular vesicles (sEVs) are nanoscale vesicles carrying biomolecules reflective of their cellular origin, making them attractive biomarkers for cancer diagnosis. In this study, we present a high-throughput strategy integrating amphiphile-...
Non-invasive preoperative assessment of HER2 status is critical for identifying candidates for targeted therapy and personalizing treatment strategies in endometrial cancer (EC). This study aims to assess the preoperative value of multiparametric mag...
. To improve survival prediction for HER2-positive breast cancer by integrating histopathological, molecular, and clinical data using a multimodal transformer framework.. We propose a multimodal transformer framework for breast cancer survival predic...
CanAssist Breast (CAB), an immunohistochemistry (IHC) and artificial intelligence-based prognostic test, was developed on Hormone receptor-positive (HR +), HER2/neu-negative (HER2-) breast tumors from Indian patients and validated in retrospective gl...
Accurate interpretation of human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) scores 0 and 1+ is crucial for treating HER2-low breast cancer patients with antibody-drug conjugates. To improve diagnostic precision, we developed...
This study integrates ultrasound Radiomics with clinical data to enhance the diagnostic accuracy of HER-2 expression status in breast cancer, aiming to provide more reliable treatment strategies for this aggressive disease. We included ultrasound ima...
Artificial intelligence and machine learning models have been developed to engineer antibodies for specific recognition of antigens. These approaches, however, often focus on the antibody complementarity-determining region (CDR) whilst ignoring the i...
Journal of computer-aided molecular design
Jul 6, 2025
The PI3K/Akt pathway plays a crucial role in regulating a broad network of proteins involved in the proliferation of HER2-positive breast cancer. The ethyl acetate fraction of Vernonia amygdalina, which contains cardiac glycosides, has been shown to ...
Neoadjuvant therapy has been widely used in breast cancer, but treatment response varies among individuals. We conducted multiomic profiling on tumor samples from 149 Chinese patients with breast cancer across ERHER2, ERHER2, and ERHER2 subtypes, cat...
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