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SAEROF: an ensemble approach for large-scale drug-disease association prediction by incorporating rotation forest and sparse autoencoder deep neural network.

Scientific reports
Drug-disease association is an important piece of information which participates in all stages of drug repositioning. Although the number of drug-disease associations identified by high-throughput technologies is increasing, the experimental methods ...

Prediction Model of Aryl Hydrocarbon Receptor Activation by a Novel QSAR Approach, DeepSnap-Deep Learning.

Molecules (Basel, Switzerland)
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that senses environmental exogenous and endogenous ligands or xenobiotic chemicals. In particular, exposure of the liver to environmental metabolism-disrupting chemicals c...

A knowledge-driven feature learning and integration method for breast cancer diagnosis on multi-sequence MRI.

Magnetic resonance imaging
BACKGROUND: The classification of benign versus malignant breast lesions on multi-sequence Magnetic Resonance Imaging (MRI) is a challenging task since breast lesions are heterogeneous and complex. Recently, deep learning methods have been used for b...

Machine learning and radiomic phenotyping of lower grade gliomas: improving survival prediction.

European radiology
BACKGROUND AND PURPOSE: Recent studies have highlighted the importance of isocitrate dehydrogenase (IDH) mutational status in stratifying biologically distinct subgroups of gliomas. This study aimed to evaluate whether MRI-based radiomic features cou...

Deep learning algorithm for surveillance of pneumothorax after lung biopsy: a multicenter diagnostic cohort study.

European radiology
OBJECTIVES: Pneumothorax is the most common and potentially life-threatening complication arising from percutaneous lung biopsy. We evaluated the performance of a deep learning algorithm for detection of post-biopsy pneumothorax in chest radiographs ...

A machine learning approach on multiscale texture analysis for breast microcalcification diagnosis.

BMC bioinformatics
BACKGROUND: Screening programs use mammography as primary diagnostic tool for detecting breast cancer at an early stage. The diagnosis of some lesions, such as microcalcifications, is still difficult today for radiologists. In this paper, we proposed...

DePicT Melanoma Deep-CLASS: a deep convolutional neural networks approach to classify skin lesion images.

BMC bioinformatics
BACKGROUND: Melanoma results in the vast majority of skin cancer deaths during the last decades, even though this disease accounts for only one percent of all skin cancers' instances. The survival rates of melanoma from early to terminal stages is mo...

Prediction of tumor location in prostate cancer tissue using a machine learning system on gene expression data.

BMC bioinformatics
BACKGROUND: Finding the tumor location in the prostate is an essential pathological step for prostate cancer diagnosis and treatment. The location of the tumor - the laterality - can be unilateral (the tumor is affecting one side of the prostate), or...