AIMC Topic: Synovial Membrane

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Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data.

PloS one Nov 8, 2019
Several studies have reported mitochondrial dysfunction in rheumatoid arthritis (RA). Many nuclear DNA (nDNA) encoded proteins translocate to mitochondria, but their participation in the dysfunction of this cell organelle during RA is quite unclear. ...
Protein Interaction Maps Arthritis, Rheumatoid Inflammation Humans Gene Expression Profiling Reactive Oxygen Species Models, Biological Mitochondria Synovial Membrane Apoptosis Mitochondrial Proteins Oxidative Phosphorylation Gene Expression Regulation Gene Ontology
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Analysis of differentially expressed genes in rheumatoid arthritis and osteoarthritis by integrated microarray analysis.

Journal of cellular biochemistry Mar 4, 2019
BACKGROUND: Rheumatoid arthritis (RA) and osteoarthritis (OA) were two major types of joint diseases. This study aimed to explore the mechanism underlying OA and RA and analyze their difference by integrated analysis of multiple gene expression data ...
Osteoarthritis Gene Expression Regulation Chemokines Signal Transduction Synovial Membrane Oligonucleotide Array Sequence Analysis Oxidative Phosphorylation Inhibitor of Apoptosis Proteins Humans Gene Expression Profiling Gene Regulatory Networks Arthritis, Rheumatoid Protein Interaction Maps Ubiquitin-Protein Ligases Gene Ontology
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Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data.

Arthritis & rheumatology (Hoboken, N.J.) Apr 2, 2018
OBJECTIVE: In this study, we sought to refine histologic scoring of rheumatoid arthritis (RA) synovial tissue by training with gene expression data and machine learning.
Gene Expression Profiling Arthritis, Rheumatoid Synovial Membrane Osteoarthritis Sequence Analysis, RNA Male Middle Aged Female Aged Humans Machine Learning
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Tenascin-C Prevents Articular Cartilage Degeneration in Murine Osteoarthritis Models.

Cartilage Dec 4, 2016
Objective The objective of this study was to determine whether intra-articular injections of tenascin-C (TNC) could prevent cartilage damage in murine models of osteoarthritis (OA). Design Fluorescently labeled TNC was injected into knee joints and i...
Cartilage Diseases Cartilage, Articular Tenascin Osteoarthritis, Knee Collagen Type II Animals Knee Joint Injections, Intra-Articular Synovial Membrane Disease Models, Animal Mice, Inbred BALB C Male Mice
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[Interleukin?22 promotes proliferation of fibroblast?like synoviocytes from patients with rheumatoid arthritis by inducing STAT3 phosphorylation].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University Dec 20, 2017
OBJECTIVE: To clarify the mechanism by which interleukin?22 (IL?22) promotes the proliferation of fibroblast?like synoviocytes (FLS) from patients with rheumatoid arthritis (RA).
Tyrphostins Synovial Membrane MAP Kinase Signaling System Interleukin-22 Humans Phosphorylation Fibroblasts Synoviocytes Interleukins Arthritis, Rheumatoid STAT3 Transcription Factor Cell Proliferation Cells, Cultured
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Predictive model of synovial membrane degradation using semi-automated morphometry and artificial neural networks.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie Jan 1, 2016
Gonarthrosis is a degenerative disease that affects mainly older people, but whose incidence has increased significantly in the last decade in population under the age of 65. The main objective of this study was developing a predictive model of synov...
Humans Neural Networks, Computer Automation Demography Female Fractals Synovial Membrane Models, Biological Middle Aged Male
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