AIMC Topic: Synovial Membrane

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Machine learning and weighted gene co-expression network analysis identify a three-gene signature to diagnose rheumatoid arthritis.

Frontiers in immunology Apr 22, 2024
BACKGROUND: Rheumatoid arthritis (RA) is a systemic immune-related disease characterized by synovial inflammation and destruction of joint cartilage. The pathogenesis of RA remains unclear, and diagnostic markers with high sensitivity and specificity...
Gene Expression Profiling Transcriptome Gene Regulatory Networks Humans Machine Learning Biomarkers Support Vector Machine Databases, Genetic Kinesins Ribonucleoside Diphosphate Reductase Arthritis, Rheumatoid Computational Biology Synovial Membrane
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Identification of Synovial Fibroblast-Associated Neuropeptide Genes and m6A Factors in Rheumatoid Arthritis Using Single-Cell Analysis and Machine Learning.

Disease markers Feb 9, 2022
OBJECTIVES: Synovial fibroblasts (SFs) play an important role in the development and progression of rheumatoid arthritis (RA). However, the pathogenic mechanism of SFs remains unclear. The objective of this study was to investigate how neuropeptides ...
Single-Cell Analysis Arthritis, Rheumatoid Synovial Membrane Fibroblasts Adenosine Neuropeptides Humans Machine Learning
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Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data.

PloS one Nov 8, 2019
Several studies have reported mitochondrial dysfunction in rheumatoid arthritis (RA). Many nuclear DNA (nDNA) encoded proteins translocate to mitochondria, but their participation in the dysfunction of this cell organelle during RA is quite unclear. ...
Oxidative Phosphorylation Reactive Oxygen Species Models, Biological Mitochondria Gene Expression Regulation Inflammation Gene Expression Profiling Gene Ontology Synovial Membrane Humans Mitochondrial Proteins Protein Interaction Maps Apoptosis Arthritis, Rheumatoid
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Analysis of differentially expressed genes in rheumatoid arthritis and osteoarthritis by integrated microarray analysis.

Journal of cellular biochemistry Mar 4, 2019
BACKGROUND: Rheumatoid arthritis (RA) and osteoarthritis (OA) were two major types of joint diseases. This study aimed to explore the mechanism underlying OA and RA and analyze their difference by integrated analysis of multiple gene expression data ...
Protein Interaction Maps Gene Regulatory Networks Arthritis, Rheumatoid Humans Gene Expression Profiling Gene Expression Regulation Chemokines Ubiquitin-Protein Ligases Signal Transduction Synovial Membrane Osteoarthritis Inhibitor of Apoptosis Proteins Gene Ontology Oligonucleotide Array Sequence Analysis Oxidative Phosphorylation
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Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data.

Arthritis & rheumatology (Hoboken, N.J.) Apr 2, 2018
OBJECTIVE: In this study, we sought to refine histologic scoring of rheumatoid arthritis (RA) synovial tissue by training with gene expression data and machine learning.
Gene Expression Profiling Arthritis, Rheumatoid Aged Sequence Analysis, RNA Male Humans Synovial Membrane Middle Aged Machine Learning Osteoarthritis Female
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Tenascin-C Prevents Articular Cartilage Degeneration in Murine Osteoarthritis Models.

Cartilage Dec 4, 2016
Objective The objective of this study was to determine whether intra-articular injections of tenascin-C (TNC) could prevent cartilage damage in murine models of osteoarthritis (OA). Design Fluorescently labeled TNC was injected into knee joints and i...
Mice Synovial Membrane Disease Models, Animal Animals Cartilage, Articular Male Osteoarthritis, Knee Tenascin Mice, Inbred BALB C Collagen Type II Knee Joint Cartilage Diseases Injections, Intra-Articular
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[Interleukin?22 promotes proliferation of fibroblast?like synoviocytes from patients with rheumatoid arthritis by inducing STAT3 phosphorylation].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University Dec 20, 2017
OBJECTIVE: To clarify the mechanism by which interleukin?22 (IL?22) promotes the proliferation of fibroblast?like synoviocytes (FLS) from patients with rheumatoid arthritis (RA).
Interleukins Cell Proliferation MAP Kinase Signaling System Interleukin-22 Humans Synoviocytes Cells, Cultured Tyrphostins Arthritis, Rheumatoid Synovial Membrane Fibroblasts Phosphorylation STAT3 Transcription Factor
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Predictive model of synovial membrane degradation using semi-automated morphometry and artificial neural networks.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie Jan 1, 2016
Gonarthrosis is a degenerative disease that affects mainly older people, but whose incidence has increased significantly in the last decade in population under the age of 65. The main objective of this study was developing a predictive model of synov...
Middle Aged Synovial Membrane Models, Biological Automation Demography Fractals Neural Networks, Computer Female Male Humans
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