AIMC Topic: Treatment Outcome

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Single-centre, prospective cohort to predict optimal individualised treatment response in multiple sclerosis (POINT-MS): a cohort profile.

BMJ open
PURPOSE: Multiple sclerosis (MS) is a chronic neurological condition that affects approximately 150 000 people in the UK and presents a significant healthcare burden, including the high costs of disease-modifying treatments (DMTs). DMTs have substant...

Using Machine Learning Methods to Predict Early Treatment Outcomes for Multidrug-Resistant or Rifampicin-Resistant Tuberculosis to Enhance Patient Cure Rates: Development and Validation of Multiple Models.

Journal of medical Internet research
BACKGROUND: Early prediction of treatment outcomes for patients with multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB) undergoing extended therapy is crucial for enhancing clinical prognoses and preventing the transmission of this ...

Enteral versus parenteral nutrition in auto-HCT: a randomized controlled trial on clinical outcomes and gut microbiome dynamics.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Disruption of the gut microbiome is a common consequence of chemotherapy, linked with detrimental treatment outcomes (e.g. sepsis), especially in haematopoietic stem cell transplant (HCT) recipients. Preclinical data suggest that enteral nutrition (E...

Protocol for a core outcome set for pharmacological treatments in hospitalised patients with acute viral respiratory infections (COSAVRI).

PloS one
BACKGROUND: Acute viral respiratory infections (AVRIs) rank among the most common causes of hospitalisation worldwide, imposing significant healthcare burdens and driving the development of pharmacological treatments. However, inconsistent outcome re...

Effects of walking training with and without a robot and standard care on clinical and mobility outcomes: A randomized clinical trial in acute ischemic stroke patients.

Experimental gerontology
BACKGROUND: Stroke incidence rises with age. A stroke can severely affect walking ability, requiring therapy. Robot-assisted walking therapy (ROB) has been advocated as one form of walking rehabilitation in stroke patients. However, its comparative e...

ROC Analysis of Biomarker Combinations in Fragile X Syndrome-Specific Clinical Trials: Evaluating Treatment Efficacy via Exploratory Biomarkers.

Translational psychiatry
Fragile X Syndrome (FXS) is a rare neurodevelopmental disorder caused by a trinucleotide repeat expansion on the 5' untranslated region of the FMR1 gene. FXS is characterized by intellectual disability, anxiety, sensory hypersensitivity, and difficul...

Soft robotic gloves versus mirror therapy: a long-term comparative study on hand function and motor recovery in post-stroke rehabilitation.

Journal of rehabilitation medicine
OBJECTIVE: This study aimed to compare the long-term effects of soft robotic gloves (SRGs) and mirror therapy on hand function and motor recovery in post-stroke patients.

Comparative analysis of outcomes in high KDPI spectrum kidney transplants using unsupervised machine learning algorithm.

PloS one
BACKGROUND: The Kidney Donor Profile Index (KDPI) is a continuous metric used to estimate the risk of allograft failure for kidneys from deceased donors. Lower KDPI scores are associated with longer post-transplant kidney function. This study aims to...

Temporal dynamics of early child-clinician prosodic synchrony predict one year autism intervention outcomes using AI driven affective computing.

Scientific reports
The patient-therapist interpersonal dynamics is a cornerstone of psychotherapy, yet how it shapes clinical outcomes remains underexplored and difficult to quantify. This is also true in autism, where interpersonal interplay is recognized as an active...