BACKGROUND: Urolithiasis, particularly anhydrous uric acid stones (AUAs), imposes significant clinical and economic burdens. Accurate preoperative differentiation of AUAs from other stone types remains challenging, yet essential for personalized pati...
Urinary glucose, creatinine, and uric acid are vital biomarkers for diabetes and kidney disease management. However, multiplex point-of-care detection faces challenges due to insufficient sensitivity in complex urine matrices and signal cross-talk fr...
BACKGROUND: Renal injury is a severe complication among individuals diagnosed with gout. This research constructed a machine learning predictive model to assess renal injury risk in gout patients.
The detection of sweat metabolites is crucial for health monitoring, disease screening, and personalized medicine. Traditional methods encounter challenges like low metabolite concentrations, complex biological matrices, and difficulty in achieving m...
Wearable sensors allow non-invasive monitoring of sweat metabolites, but their reliance on molecular recognition elements limits both physiological coverage and temporal resolution. Here we report an all-flexible chronoepifluidic surface-enhanced Ram...
The composition of urinary calculi serves as a critical determinant for personalized surgical strategies; however, such compositional data are often unavailable preoperatively. This study aims to develop a machine learning-based preoperative predicti...
Traditional wearable devices for sweat detection often face limitations such as low detection sensitivity, insufficient mechanical properties, and discomfort during use. To address these challenges, hydrogels are utilized as sensor patches to improve...
Analytical methods : advancing methods and applications
Jul 17, 2025
Metabolic molecules are highly correlated with various physiological indicators and diseases, so it is particularly important to monitor the levels of multiple metabolites in the body. Due to the similar electrochemical properties of uric acid (UA), ...
Hyperuricemia (HUA) and gout result from imbalances in uric acid metabolism and are closely associated with the gut microbiota. Advanced analytical methods facilitate the exploration of microbiota complexity. In this study, 16S rRNA sequencing data f...
BACKGROUND: In humans, uric acid is a product of purine metabolism that impacts the vascular system. In addition to effects on arterial vascular tone, associations between serum uric acid concentrations-even in the physiological range-and arterial hy...
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