OBJECTIVE: To evaluate the effect of preoperative intake of oral carbohydrates versus standard preoperative fasting prior to elective cesarean delivery on plasma purine levels (hypoxanthine, xanthine, and uric acid) and beta-hydroxybutyrate (β-HB) in...
Insulin resistance (IR) is the core for type 2 diabetes and metabolic syndrome. The homeostasis assessment model is a straightforward and practical tool for quantifying insulin resistance (HOMA-IR). Multiple adaptive regression spline (MARS) is a mac...
OBJECTIVES: Urinary stones composed of uric acid can be treated with medicine. Computed tomography (CT) can diagnose urinary stone disease, but it is difficult to predict the type of uric stones. This study aims to develop a method to distinguish pur...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
39509865
Metabolites serve as vital biomarkers, reflecting physiological and pathological states and offering insights into disease progression and early detection. This study introduces an advanced analytical technique integrating label-free Surface-Enhanced...
OBJECTIVE: To develop a machine learning (ML) model using clinical data and ultrasound features for gout prediction, and apply SHapley Additive exPlanations (SHAP) for model interpretation.
Elevated levels of uric acid (UA) in the body may not only lead to the formation of stones but also increase the risk of developing chronic kidney disease (CKD). This study presents a biosensor for detecting UA concentration in stones and a deep lear...
Uric acid is a key metabolic byproduct of purine degradation and plays a dual role in human health. At physiological levels, it acts as an antioxidant, protecting against oxidative stress. However, excessive uric acid can lead to hyperuricemia, cont...
In hyperuricaemic populations, multiple factors may contribute to impaired renal function. This study aimed to establish a machine learning-based model to identify characteristic factors related to renal impairment in hyperuricaemic patients, determi...
International journal of rheumatic diseases
40269465
BACKGROUND: Individuals with hyperuricemia (HUA) are widely recognized as being at increased risk for gout. This study aimed to investigate how physical activity (PA) duration and sedentary duration impact gout risk in individuals with HUA and to dev...
OBJECTIVES: Stage ≥3 chronic kidney disease (CKD) affects ∼25% of people with gout. The effects of urate-lowering therapy (ULT) on CKD incidence and progression have remained inconclusive. Here, we assessed the impact of a gout ULT clinic interventio...