Proceedings of the National Academy of Sciences of the United States of America
Jul 30, 2025
Past traumatic experiences shape neural responses to future stress, but the mechanisms underlying this dynamic interaction remain unclear. Here, we assessed how trauma-related brain networks respond to current acute stress in real time. Using a machi...
BACKGROUND: Identifying key characteristics of unknown suspects, such as age, height, and drug use, is essential for advancing forensic investigations.
BACKGROUND: The escalating mental health crisis during and post-COVID-19 underscores the urgent need for scalable, timely, cost-effective assessment solutions for general psychotic disorders. Regretfully, traditional symptom-based, one-to-one assessm...
Human prefrontal areas show enhanced activations when individuals are presented with images, under diverse task conditions. However, the functional role of these increased activations remains a deeply debated question. Here we addressed this question...
BACKGROUND: The use of conversational agents (CAs) in mental health therapy is gaining traction due to their accessibility, anonymity, and nonjudgmental nature. However, understanding the psychological factors driving preferences for CA-based therapy...
BACKGROUND: The rapid advancements in artificial intelligence (AI) technologies across various sectors, including health care, necessitate the need for a comprehensive understanding of their applications. Specifically, the acceptance and readiness of...
BACKGROUND: Depressive symptoms are highly prevalent in first-episode psychosis (FEP) and worsen clinical outcomes. It is currently difficult to determine which patients will have persistent depressive symptoms based on a clinical assessment. We aime...
Accurate pain assessment is essential for effective management; however, most studies have focused on differentiating pain from non-pain or estimating pain intensity rather than distinguishing between distinct pain types. We present a machine learnin...
BACKGROUND: Obesity is a known risk factor for breast cancer (BC), but conventional metrics such as body mass index (BMI) may insufficiently capture central adiposity. The weight-adjusted waist index (WWI) has emerged as a potentially superior anthro...
Despite the critical role of DNA methylation, clinical implementations harnessing its promise have not been described in acute myeloid leukemia. Utilizing DNA methylation from 3314 leukemia patient samples across 11 harmonized cohorts, we describe th...
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