AI Medical Compendium Journal:
International journal of antimicrobial agents

Showing 1 to 9 of 9 articles

Comparison of population pharmacokinetic modeling and machine learning approaches for predicting voriconazole trough concentrations in critically ill patients.

International journal of antimicrobial agents Dec 26, 2024
BACKGROUND: Despite the widespread use of voriconazole in antifungal treatment, its high pharmacokinetic and pharmacodynamic variability may lead to suboptimal efficacy, especially in intensive care unit (ICU) patients. Machine learning (ML), an arti...
Humans Machine Learning Critical Illness Male Middle Aged Antifungal Agents Bayes Theorem Intensive Care Units Female Aged Adult Voriconazole
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Novel active Trp- and Arg-rich antimicrobial peptides with high solubility and low red blood cell toxicity designed using machine learning tools.

International journal of antimicrobial agents Dec 5, 2024
BACKGROUND: Given the rising number of multidrug-resistant (MDR) bacteria, there is a need to design synthetic antimicrobial peptides (AMPs) that are highly active, non-hemolytic, and highly soluble. Machine learning tools allow the straightforward i...
CHO Cells Solubility Inhibitory Concentration 50 Erythrocytes Tryptophan Hemolysis Antimicrobial Peptides Humans Machine Learning Anti-Bacterial Agents Animals Microbial Sensitivity Tests Methicillin-Resistant Staphylococcus aureus Antimicrobial Cationic Peptides
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Machine learning accelerates the discovery of epitope-based dual-bioactive peptides against skin infections.

International journal of antimicrobial agents Oct 31, 2024
OBJECTIVES: Skin injuries and infections are an inevitable part of daily human life, particularly with chronic wounds, becoming an increasing socioeconomic burden. In treating skin infections and promoting wound healing, bioactive peptides may hold s...
Mice Escherichia coli Wound Healing Disease Models, Animal Machine Learning Cytokines Animals Male Skin Antimicrobial Peptides Histocompatibility Antigens Class II Skin Diseases, Infectious Humans Lipopolysaccharides Antimicrobial Cationic Peptides Anti-Inflammatory Agents Epitopes
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Accurate prediction of antimicrobial resistance and genetic marker of Staphylococcus aureus clinical isolates using MALDI-TOF MS and machine learning - across DRIAMS and Taiwan database.

International journal of antimicrobial agents Sep 6, 2024
BACKGROUND: The use of matrix-assisted laser desorption/ionisation-time-of-flight mass spectra (MALDI-TOF MS) with machine learning (ML) has been explored for predicting antimicrobial resistance. This study evaluates the effectiveness of MALDI-TOF MS...
Oxacillin Genetic Markers Staphylococcal Infections Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Penicillin-Binding Proteins Machine Learning Anti-Bacterial Agents Drug Resistance, Bacterial Humans Databases, Factual Microbial Sensitivity Tests Staphylococcus aureus Taiwan Bacterial Proteins
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Machine learning algorithms to predict colistin-induced nephrotoxicity from electronic health records in patients with multidrug-resistant Gram-negative infection.

International journal of antimicrobial agents Apr 19, 2024
OBJECTIVES: Colistin-induced nephrotoxicity prolongs hospitalisation and increases mortality. The study aimed to construct machine learning models to predict colistin-induced nephrotoxicity in patients with multidrug-resistant Gram-negative infection...
ROC Curve Colistin Gram-Negative Bacterial Infections Adult Male Middle Aged Drug Resistance, Multiple, Bacterial Humans Machine Learning Algorithms Anti-Bacterial Agents Retrospective Studies Electronic Health Records Female Aged
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Antibiotic combinations prediction based on machine learning to multicentre clinical data and drug interaction correlation.

International journal of antimicrobial agents Feb 29, 2024
BACKGROUND: With increasing antibiotic resistance and regulation, the issue of antibiotic combination has been emphasised. However, antibiotic combination prescribing lacks a rapid identification of feasibility, while its risk of drug interactions is...
Retrospective Studies Bacterial Infections Drug Interactions Drug Therapy, Combination Humans Machine Learning Algorithms Anti-Bacterial Agents
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Dalbavancin in-vitro activity obtained against Gram-positive clinical isolates causing bone and joint infections in US and European hospitals (2011-2016).

International journal of antimicrobial agents Dec 23, 2017
BACKGROUND: Osteomyelitis is a difficult-to-treat infection that regularly involves prolonged use of systemic antibiotics. Dalbavancin has demonstrated activity against Gram-positive isolates, and has been considered as a candidate for the treatment ...
Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Teicoplanin United States Europe Humans Osteomyelitis Staphylococcus aureus Staphylococcal Infections Anti-Bacterial Agents Streptococcal Infections Viridans Streptococci Enterococcus faecalis
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Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients.

International journal of antimicrobial agents Dec 22, 2017
Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models constructed with intermittent infusion data. However, the probability of targ...
Piperacillin Pseudomonas Infections Kidney Function Tests Pseudomonas aeruginosa Drug Combinations Humans Tazobactam Infusions, Intravenous Anti-Bacterial Agents Metabolic Clearance Rate Creatinine Critical Illness Male Penicillanic Acid Female Middle Aged Sepsis Microbial Sensitivity Tests
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Efavirenz pharmacogenetics in a cohort of Italian patients.

International journal of antimicrobial agents Dec 18, 2015
The pharmacogenetics and pharmacokinetics of efavirenz (EFV) have been widely studied, although data in the Italian population are limited. Single nucleotide polymorphisms (SNPs) in the CYP2B6 gene have been associated with increased EFV plasma conce...
Cyclopropanes Italy HIV-1 Humans Polymerase Chain Reaction Plasma Constitutive Androstane Receptor Alkynes Benzoxazines Middle Aged Pharmacogenetics Anti-HIV Agents Polymorphism, Single Nucleotide Retrospective Studies Female Adult Male
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