BACKGROUND: Prior studies have elucidated that alterations in gut microbiota are associated with a spectrum of tumors and metabolic disorders. However, the diagnostic value of gut microbiota in epithelial ovarian cancer remains insufficiently investi...
BACKGROUND: Advancements in artificial intelligence (AI) and machine learning (ML) have revolutionized the medical field and transformed translational medicine. These technologies enable more accurate disease trajectory models while enhancing patient...
BACKGROUND: The presence of tumour-infiltrating lymphocytes (TILs) is a well-established prognostic biomarker across multiple cancer types, with higher TIL counts being associated with lower recurrence rates and improved patient survival. We aimed to...
BACKGROUND: Postpartum depression (PPD) is a significant public health issue. This study aimed to develop and validate machine learning (ML) models using biopsychosocial predictors to predict the risk of PPD for perinatal women and to provide several...
BACKGROUND: Single-cell multi-omics technologies, particularly single-cell RNA sequencing (scRNA-seq), have revolutionized our understanding of cellular heterogeneity and development by providing insights into gene expression at the single-cell level...
BACKGROUND: Homologous recombination deficiency (HRD) refers to the dysfunction of homologous recombination repair (HRR) at the cellular level. The assessment of HRD status has the important significance for the formulation of treatment plans, effica...
BACKGROUND: Structural variations (SVs) are a pervasive and impactful class of genetic variation within the genome, significantly influencing gene function, impacting human health, and contributing to disease. Recent advances in deep learning have sh...
BACKGROUND: Predicting long-term outcomes in liver transplantation remain a challenging endeavor. This research aims to harness the power of deep learning to develop an advanced prognostic model for assessing long-term outcomes, with a specific focus...
The revolutionary CRISPR-Cas9 system leverages a programmable guide RNA (gRNA) and Cas9 proteins to precisely cleave problematic regions within DNA sequences. This groundbreaking technology holds immense potential for the development of targeted ther...