AIMC Topic: Aged

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Survival impact of adjuvant radiotherapy in early stage low risk elderly male breast cancer patients treated with breast conserving surgery.

Scientific reports
Our study aimed to evaluate the survival impact of adjuvant radiotherapy (RT) following breast-conserving surgery (BCS) in elderly male patients with early-stage, low-risk breast cancer (node-negative, HR+), and to identify RT-benefiting subgroups us...

Machine learning to predict bacteriuria in the emergency department.

Scientific reports
Urinary tract infections (UTIs) are among the most common bacterial infections, yet they are both frequently misdiagnosed and inappropriately treated. We aimed to determine whether a machine learning model could accurately predict bacteriuria by usin...

Development and validation of a machine learning-based survival prediction model for Asian glioblastoma patients using the SEER database and Chinese data.

Scientific reports
Glioblastoma is an aggressive, malignant primary brain tumour and the most prevalent histological type of glioma. Our study attempted to investigate the independent predictors of overall survival (OS) and cancer-specific survival (CSS) in Asian patie...

A novel MRI-based habitat analysis and deep learning for predicting perineural invasion in prostate cancer: a two-center study.

BMC cancer
BACKGROUND: To explore the efficacy of a deep learning (DL) model in predicting perineural invasion (PNI) in prostate cancer (PCa) by conducting multiparametric MRI (mpMRI)-based tumor heterogeneity analysis.

Aging associated immunosenescence in rheumatoid arthritis identified by machine learning and single cell profiling.

Scientific reports
Rheumatoid arthritis (RA) is increasingly prevalent among older adults, who often experience more severe symptoms and face significant treatment challenges. This study aims to identify specific genes associated with aging in RA and to analyze their i...

Association between the COVID-19 pandemic and cardiopulmonary function in acute coronary syndrome patients without SARS-CoV-2 infection.

Scientific reports
The COVID-19 pandemic disrupted cardiovascular disease management. This single-center cross-sectional cohort study evaluated cardiopulmonary function changes in acute coronary syndrome (ACS) patients post-percutaneous coronary intervention (PCI) with...

Circulating proteins and metabolites panel for noninvasive preoperative diagnosis of epithelial ovarian cancer.

BMC medicine
BACKGROUND: Existing biomarkers for epithelial ovarian cancer (EOC) have demonstrated limited sensitivity and specificity. This study aimed to investigate plasma protein and metabolite characteristics of EOC and identify novel biomarker candidates fo...

Study on the mechanisms associating community outdoor public spaces with elderly behavior.

Scientific reports
As the global population ages, enhancing community outdoor public spaces to accommodate the needs of senior citizens has emerged as a critical challenge. This research delves into the intricate relationship between community outdoor public spaces and...

Radiomics early assessment of post chemotherapy cardiotoxicity in cancer patients using 2D echocardiography imaging an interpretable machine learning study.

Scientific reports
Cardiotoxicity is the loss of the heart muscle's ability to contract effectively, often due to chemotherapy or radiation therapy. This study uses interpretable machine learning to predict post-chemotherapy cardiotoxicity using radiomics features extr...