AIMC Topic: Aging

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Deep Learning to Estimate Biological Age From Chest Radiographs.

JACC. Cardiovascular imaging
OBJECTIVES: The goal of this study was to assess whether a deep learning estimate of age from a chest radiograph image (CXR-Age) can predict longevity beyond chronological age.

Explainable AI reveals changes in skin microbiome composition linked to phenotypic differences.

Scientific reports
Alterations in the human microbiome have been observed in a variety of conditions such as asthma, gingivitis, dermatitis and cancer, and much remains to be learned about the links between the microbiome and human health. The fusion of artificial inte...

Identification of drug combinations on the basis of machine learning to maximize anti-aging effects.

PloS one
Aging is a multifactorial process that involves numerous genetic changes, so identifying anti-aging agents is quite challenging. Age-associated genetic factors must be better understood to search appropriately for anti-aging agents. We utilized an ag...

Associated factors of white matter hyperintensity volume: a machine-learning approach.

Scientific reports
To identify the most important parameters associated with cerebral white matter hyperintensities (WMH), in consideration of potential collinearity, we used a data-driven machine-learning approach. We analysed two independent cohorts (KORA and SHIP). ...

Machine Learning Analysis of Longevity-Associated Gene Expression Landscapes in Mammals.

International journal of molecular sciences
One of the important questions in aging research is how differences in transcriptomics are associated with the longevity of various species. Unfortunately, at the level of individual genes, the links between expression in different organs and maximum...

Vascular Aging Detected by Peripheral Endothelial Dysfunction Is Associated With ECG-Derived Physiological Aging.

Journal of the American Heart Association
Background An artificial intelligence algorithm that detects age using the 12-lead ECG has been suggested to signal "physiologic age." This study aimed to investigate the association of peripheral microvascular endothelial function (PMEF) as an index...

ARDD 2020: from aging mechanisms to interventions.

Aging
Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead t...