AIMC Topic: alpha-Fetoproteins
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Integrating Machine Learning and Follow-Up Variables to Improve Early Detection of Hepatocellular Carcinoma in Tyrosinemia Type 1: A Multicenter Study.
International journal of molecular sciences
Apr 18, 2025
Hepatocellular carcinoma (HCC) is a major complication of tyrosinemia type 1 (HT-1), an inborn error of metabolism affecting tyrosine catabolism. The risk of HCC is higher in late diagnoses despite treatment. Alpha-fetoprotein (AFP) is widely used to...
Infant
Adolescent
Child, Preschool
Child
Adult
Biomarkers, Tumor
Male
Middle Aged
Early Detection of Cancer
alpha-Fetoproteins
Alkaline Phosphatase
Alanine Transaminase
Tyrosinemias
Liver Neoplasms
Carcinoma, Hepatocellular
Longitudinal Studies
Follow-Up Studies
Humans
Machine Learning
Retrospective Studies
Female
Infant, Newborn
Young Adult
Development of machine learning-based personalized predictive models for risk evaluation of hepatocellular carcinoma in hepatitis B virus-related cirrhosis patients with low levels of serum alpha-fetoprotein.
Annals of hepatology
Aug 15, 2024
INTRODUCTION AND OBJECTIVES: The increasing incidence of hepatocellular carcinoma (HCC) in China is an urgent issue, necessitating early diagnosis and treatment. This study aimed to develop personalized predictive models by combining machine learning...
Biomarker profiling and integrating heterogeneous models for enhanced multi-grade breast cancer prognostication.
Computer methods and programs in biomedicine
Jul 22, 2024
BACKGROUND: Breast cancer remains a leading cause of female mortality worldwide, exacerbated by limited awareness, inadequate screening resources, and treatment options. Accurate and early diagnosis is crucial for improving survival rates and effecti...
Enhancing the diagnostic accuracy of colorectal cancer through the integration of serum tumor markers and hematological indicators with machine learning algorithms.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Jun 20, 2024
BACKGROUND: Colorectal cancer has a high incidence and mortality rate due to a low rate of early diagnosis. Therefore, efficient diagnostic methods are urgently needed.
Development of a machine learning-based model to predict prognosis of alpha-fetoprotein-positive hepatocellular carcinoma.
Journal of translational medicine
May 13, 2024
BACKGROUND: Patients with alpha-fetoprotein (AFP)-positive hepatocellular carcinoma (HCC) have aggressive biological behavior and poor prognosis. Therefore, survival time is one of the greatest concerns for patients with AFP-positive HCC. This study ...
Application of Machine Learning Techniques to Assess Alpha-Fetoprotein at Diagnosis of Hepatocellular Carcinoma.
International journal of molecular sciences
Feb 7, 2024
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and is associated with high mortality rates. Approximately 80% of cases occur in cirrhotic livers, posing a significant challenge for appropriate therapeutic management. Adequate s...
Machine learning-based delta check method for detecting misidentification errors in tumor marker tests.
Clinical chemistry and laboratory medicine
Dec 14, 2023
OBJECTIVES: Misidentification errors in tumor marker tests can lead to serious diagnostic and treatment errors. This study aims to develop a method for detecting these errors using a machine learning (ML)-based delta check approach, overcoming limita...
MRI-based deep learning model for differentiation of hepatic hemangioma and hepatoblastoma in early infancy.
European journal of pediatrics
Jul 18, 2023
UNLABELLED: Hepatic hemangioma (HH) and hepatoblastoma (HBL) are common pediatric liver tumors and present with similar clinical manifestations with limited distinguishing value of serum AFP in early infancy. An accurate differentiation diagnostic to...
Deep-learning-based analysis of preoperative MRI predicts microvascular invasion and outcome in hepatocellular carcinoma.
World journal of surgical oncology
Jun 8, 2022
BACKGROUND: Preoperative prediction of microvascular invasion (MVI) is critical for treatment strategy making in patients with hepatocellular carcinoma (HCC). We aimed to develop a deep learning (DL) model based on preoperative dynamic contrast-enhan...
Role of α-fetoprotein in differentiation of regulatory T lymphocytes.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
Jan 4, 2018
The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4 lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-prolife...
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