AIMC Topic: Animals

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Comparing Multiple Machine Learning Algorithms and Metrics for Estrogen Receptor Binding Prediction.

Molecular pharmaceutics
Many chemicals that disrupt endocrine function have been linked to a variety of adverse biological outcomes. However, screening for endocrine disruption using in vitro or in vivo approaches is costly and time-consuming. Computational methods, e.g., q...

A deep convolutional neural network approach for astrocyte detection.

Scientific reports
Astrocytes are involved in various brain pathologies including trauma, stroke, neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, or chronic pain. Determining cell density in a complex tissue environment in microscopy images an...

Bio-inspired upper limb soft exoskeleton to reduce stroke-induced complications.

Bioinspiration & biomimetics
Stroke has become the leading cause of disability and the second-leading cause of mortality worldwide. Dyskinesia complications are the major reason of these high death and disability rates. As a tool for rapid motion function recovery in stroke pati...

Management practices associated with strongylid parasite prevalence on horse farms in rural counties of Kentucky.

Veterinary parasitology, regional studies and reports
Anthelmintic resistance among cyathostomin parasites is a wide-spread problem. The parasite control guidelines written by the American Association of Equine Practitioners (AAEP) encourages the preservation of anthelmintic efficacy by reducing treatme...

Comparison of response surface methodology and artificial neural network to optimize novel ophthalmic flexible nano-liposomes: Characterization, evaluation, in vivo pharmacokinetics and molecular dynamics simulation.

Colloids and surfaces. B, Biointerfaces
To improve the topical delivery of pilocarpine hydrochloride (PN) to treat glaucoma, flexible nano-liposomes containing PN (PN-FLs) were prepared, optimized and characterized. Artificial neural network (ANN) and response surface methodology (RSM) wer...

Machine learning in major depression: From classification to treatment outcome prediction.

CNS neuroscience & therapeutics
AIMS: Major depression disorder (MDD) is the single greatest cause of disability and morbidity, and affects about 10% of the population worldwide. Currently, there are no clinically useful diagnostic biomarkers that are able to confirm a diagnosis of...

Morphological intelligence counters foot slipping in the desert locust and dynamic robots.

Proceedings of the National Academy of Sciences of the United States of America
During dynamic terrestrial locomotion, animals use complex multifunctional feet to extract friction from the environment. However, whether roboticists assume sufficient surface friction for locomotion or actively compensate for slipping, they use rel...

DeepLabCut: markerless pose estimation of user-defined body parts with deep learning.

Nature neuroscience
Quantifying behavior is crucial for many applications in neuroscience. Videography provides easy methods for the observation and recording of animal behavior in diverse settings, yet extracting particular aspects of a behavior for further analysis ca...