AIMC Topic: Animals
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Root of Prunus persica (taoshugen) ameliorated renal fibrosis by inhibiting TGF-β signaling via upregulating Pmepa1 in mice with unilateral ureter obstruction.
Journal of ethnopharmacology
Apr 3, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Various parts of Prunus persica (L.) Batsch (peach) exhibit medicinal properties and are utilized in traditional Chinese medicine (TCM) for therapeutic purposes. Notably, the root of P. persica, referred to as "taoshug...
AI models uncover factors influencing scorpionism in Northern Brazil.
Toxicon : official journal of the International Society on Toxinology
Apr 3, 2025
Envenomation by scorpion stings is a serious public health problem in tropical regions of the world. In Brazil's Northern region, there has been a significant increase in cases over the last decade, accompanied by a rise in the fatality rate. Climate...
Does infection alter antifungal distribution: an animal model exploring pharmacokinetic changes.
Future microbiology
Apr 3, 2025
AIM: Assessing the disseminated meningitis caused by in Wistar rats and its impact on antifungal distribution by microdialysis (µD).
Using deep learning artificial intelligence for sex identification and taxonomy of sand fly species.
PloS one
Apr 3, 2025
Sandflies are vectors for several tropical diseases such as leishmaniasis, bartonellosis, and sandfly fever. Moreover, sandflies exhibit species-specificity in transmitting particular pathogen species, with females being responsible for disease trans...
Machine learning for automated electrical penetration graph analysis of aphid feeding behavior: Accelerating research on insect-plant interactions.
PloS one
Apr 3, 2025
The electrical penetration graph (EPG) is a well-known technique that provides insights into the feeding behavior of insects with piercing-sucking mouthparts, mostly hemipterans. Since its inception in the 1960s, EPG has become indispensable in study...
Sulforaphane protects developing neural networks from VPA-induced synaptic alterations.
Molecular psychiatry
Apr 2, 2025
Prenatal brain development is particularly sensitive to chemicals that can disrupt synapse formation and cause neurodevelopmental disorders. In most cases, such chemicals increase cellular oxidative stress. For example, prenatal exposure to the anti-...
Therapeutic potential of allosteric HECT E3 ligase inhibition.
Cell
Apr 2, 2025
Targeting ubiquitin E3 ligases is therapeutically attractive; however, the absence of an active-site pocket impedes computational approaches for identifying inhibitors. In a large, unbiased biochemical screen, we discover inhibitors that bind a crypt...
Niuhuang jiedu prescription alleviates realgar-induced dopaminergic and GABAergic neurotoxicity in Caenorhabditis elegans.
Journal of ethnopharmacology
Apr 2, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Niuhuang Jiedu (NHJD) is a Chinese medicine prescription containing realgar (AsS), which is neurotoxic, and seven other traditional Chinese medicines (TCMs). However, whether the multiple TCMs contained in NHJD can mit...
Shengxuebao Mixture improves carboplatin-induced anemia by inhibiting apoptosis and ferroptosis.
Journal of ethnopharmacology
Apr 2, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Shengxuebao Mixture (SXB) is a traditional Chinese medicine which has been widely used on treating Chemotherapy-induced leukopenia and multiple anemia. It remains unclear whether SXB has a role in chemotherapeutic-indu...
Production of bioactive peptides by high-voltage pulsed electric field: Protein extraction, mechanism, research status and collaborative application.
Food chemistry
Apr 1, 2025
Bioactive peptides exhibit a variety of potential applications in the fields of medicine, food and cosmetics. However, studies have shown that the traditional preparation is characterized by low efficiency, substantial pollution, limited activities a...
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