AIMC Topic: Animals

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Identification of Multi-Functional Enzyme with Multi-Label Classifier.

PloS one
Enzymes are important and effective biological catalyst proteins participating in almost all active cell processes. Identification of multi-functional enzymes is essential in understanding the function of enzymes. Machine learning methods perform bet...

High-throughput liquid chromatography tandem mass spectrometry method for simultaneous determination of fampridine, paroxetine, and quinidine in rat plasma: Application to in vivo perfusion study.

Journal of food and drug analysis
A selective and high-throughput liquid chromatography-mass spectrometry method has been developed and validated for the simultaneous quantification of paroxetine, fampridine, and quinidine in rat plasma using imipramine as an internal standard. Follo...

Fish-inspired robots: design, sensing, actuation, and autonomy--a review of research.

Bioinspiration & biomimetics
Underwater robot designs inspired by the behavior, physiology, and anatomy of fishes can provide enhanced maneuverability, stealth, and energy efficiency. Over the last two decades, robotics researchers have developed and reported a large variety of ...

Demixed principal component analysis of neural population data.

eLife
Neurons in higher cortical areas, such as the prefrontal cortex, are often tuned to a variety of sensory and motor variables, and are therefore said to display mixed selectivity. This complexity of single neuron responses can obscure what information...

Monitoring of total positive end-expiratory pressure during mechanical ventilation by artificial neural networks.

Journal of clinical monitoring and computing
Ventilation treatment of acute lung injury (ALI) requires the application of positive airway pressure at the end of expiration (PEEP) to avoid lung collapse. However, the total pressure exerted on the alveolar walls (PEEP) is the sum of PEEP and intr...

Investigation of the mutagenic and genotoxic activities of LLL-3, a STAT3 inhibitor.

Drug and chemical toxicology
LLL-3, an anthracene derived compound, has been shown to be a promising therapeutic agent for the treatment of some kinds of cancer such as chronic myeloid leukemia and glioblastoma. However, no data regarding the toxic properties of this compound ha...

A Computational Framework for Realistic Retina Modeling.

International journal of neural systems
Computational simulations of the retina have led to valuable insights about the biophysics of its neuronal activity and processing principles. A great number of retina models have been proposed to reproduce the behavioral diversity of the different v...

Review: Milking robot utilization, a successful precision livestock farming evolution.

Animal : an international journal of animal bioscience
Automatic milking systems (AMS), one of the earliest precision livestock farming developments, have revolutionized dairy farming around the world. While robots control the milking process, there have also been numerous changes to how the whole farm s...

A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts.

PLoS computational biology
O-linked glycosylation is an important post-translational modification of mucin-type protein, changes to which are important biomarkers of cancer. For this study of the enzymes of O-glycosylation, we developed a shorthand notation for representing Ga...

RegenBase: a knowledge base of spinal cord injury biology for translational research.

Database : the journal of biological databases and curation
Spinal cord injury (SCI) research is a data-rich field that aims to identify the biological mechanisms resulting in loss of function and mobility after SCI, as well as develop therapies that promote recovery after injury. SCI experimental methods, da...