Multiple sclerosis (MS) is a multifaceted, chronic neuroinflammatory condition of the central nervous system (CNS) marked by demyelination, gliosis, and axonal degradation. Despite the comprehensive investigation, the exact etiology remains unclear, ...
Transplantation of donor grafts recellularized with recipient-derived or non-immunogenic universal cells is a potential means of reducing the graft rejection and post-transplant complications in lung transplantation. Achieving a fully recellularized ...
Antibodies play a crucial role in our immune system. Their ability to bind to and neutralize pathogens opens opportunities to develop antibodies for therapeutic and diagnostic use. Computational methods capable of designing antibodies for a target an...
Journal of chemical information and modeling
Jul 18, 2025
Acute dermal toxicity testing is essential for assessing the safety of chemicals used in pharmaceuticals, pesticides, cosmetics, and industrial chemicals. Conventional toxicity testing methods rely significantly on animal tests, which are resource-in...
The potential for food contact chemicals to disrupt genetic programs in development and metabolism raises concerns. Nuclear receptors (NRs) control many of these programs, and the retinoid-X receptor (RXR) is a DNA-binding partner for one-third of th...
Seafood, including fish, prawns and various marine products, is a critical component of global nutrition due to its high protein content, essential fatty acids, vitamins and minerals. Traditional methods for assessing seafood freshness such as sensor...
Caenorhabditis elegans is a widely used animal model for researching new disease treatments. In recent years, automated methods have been developed to extract mobility phenotypes and analyse, using statistical methods, whether there are differences b...
Single-cell spatial transcriptomics can provide subcellular resolution for a deep understanding of molecular mechanisms. However, accurate segmentation and annotation remain a major challenge that limits downstream analysis. Current machine learning ...
To evaluate scientific literature regarding the application of Photobiomodulation (PBM), with a special focus on Multiwave Locked System (MLS) laser therapy, an innovative machine learning method was used. PBM therapy has occurred as a non-invasive t...
Myocardial infarction, a leading cause of mortality worldwide, leaves survivors at significant risk of recurrence caused by scar-related re-entrant ventricular tachyarrhythmias. Effective treatment with ablation therapy requires a precise guidance sy...
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