AIMC Topic: Animals

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Magnetic nanoparticles and nanocomposites for remote controlled therapies.

Journal of controlled release : official journal of the Controlled Release Society
This review highlights the state-of-the-art in the application of magnetic nanoparticles (MNPs) and their composites for remote controlled therapies. Novel macro- to nano-scale systems that utilize remote controlled drug release due to actuation of M...

Pharmacokinetic comparison of different flubendazole formulations in pigs: A further contribution to its development as a macrofilaricide molecule.

International journal for parasitology. Drugs and drug resistance
Despite the well established ivermectin activity against microfilaria, the success of human filariasis control programmes requires the use of a macrofilaricide compound. Different in vivo trials suggest that flubendazole (FLBZ), an anthelmintic benzi...

Characterization and machine learning prediction of allele-specific DNA methylation.

Genomics
A large collection of Single Nucleotide Polymorphisms (SNPs) has been identified in the human genome. Currently, the epigenetic influences of SNPs on their neighboring CpG sites remain elusive. A growing body of evidence suggests that locus-specific ...

Implicit Value Updating Explains Transitive Inference Performance: The Betasort Model.

PLoS computational biology
Transitive inference (the ability to infer that B > D given that B > C and C > D) is a widespread characteristic of serial learning, observed in dozens of species. Despite these robust behavioral effects, reinforcement learning models reliant on rewa...

Impact of sub and supra-threshold adaptation currents in networks of spiking neurons.

Journal of computational neuroscience
Neuronal adaptation is the intrinsic capacity of the brain to change, by various mechanisms, its dynamical responses as a function of the context. Such a phenomena, widely observed in vivo and in vitro, is known to be crucial in homeostatic regulatio...

Hippocampome.org: a knowledge base of neuron types in the rodent hippocampus.

eLife
Hippocampome.org is a comprehensive knowledge base of neuron types in the rodent hippocampal formation (dentate gyrus, CA3, CA2, CA1, subiculum, and entorhinal cortex). Although the hippocampal literature is remarkably information-rich, neuron proper...

PathwaysWeb: a gene pathways API with directional interactions, expanded gene ontology, and versioning.

Bioinformatics (Oxford, England)
UNLABELLED: PathwaysWeb is a resource-based, well-documented web system that provides publicly available information on genes, biological pathways, Gene Ontology (GO) terms, gene-gene interaction networks (importantly, with the directionality of inte...

Analyzing animal behavior via classifying each video frame using convolutional neural networks.

Scientific reports
High-throughput analysis of animal behavior requires software to analyze videos. Such software analyzes each frame individually, detecting animals' body parts. But the image analysis rarely attempts to recognize "behavioral states"-e.g., actions or f...

PDON: Parkinson's disease ontology for representation and modeling of the Parkinson's disease knowledge domain.

Theoretical biology & medical modelling
BACKGROUND: Despite the unprecedented and increasing amount of data, relatively little progress has been made in molecular characterization of mechanisms underlying Parkinson's disease. In the area of Parkinson's research, there is a pressing need to...

Artificial Neural Network applied as a methodology of mosquito species identification.

Acta tropica
There are about 200 species of mosquitoes (Culicidae) known to be vectors of pathogens that cause diseases in humans. Correct identification of mosquito species is an essential step in the development of effective control strategies for these disease...