AIMC Topic: Anti-Bacterial Agents
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Development and evaluation of a direct disk diffusion, rapid antimicrobial susceptibility testing method from blood culture positive for Gram-negative bacilli using rapid molecular testing and microbiology laboratory automation.
Microbiology spectrum
May 15, 2025
Rapid antimicrobial susceptibility testing (RAST) using disk diffusion (DD) from positive blood cultures (BC) can aid initiation of effective antimicrobial therapy. Rapid molecular blood culture identification panels (BCID) and microbiology laborator...
Predicting infections with multidrug-resistant organisms (MDROs) in neurocritical care patients with hospital-acquired pneumonia (HAP): development of a novel multivariate prediction model.
Microbiology spectrum
May 15, 2025
Hospital-acquired pneumonia (HAP) is prevalent in the neuro-intensive care unit (NICU), significantly increasing susceptibility to infections with multidrug-resistant organisms (MDROs), which result in high mortality rates and substantial healthcare ...
Defining the biomarkers in anti-MRSA fractions of soil Streptomycetes by multivariate analysis.
Antonie van Leeuwenhoek
May 10, 2025
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most alarming antibiotic-resistant pathogens causing nosocomial and community-acquired infections. Actinomycetes, particularly Streptomycetes, have historically been a major source of n...
Comparative study on antibacterial activities and removal of iron ions from water using novel modified sand with silver through the hydrothermal technique.
Scientific reports
May 8, 2025
The hydrothermal-calcination technique was used to modify raw sand with silver (Ag) at different weight percentages: 2%, 5%, and 10% using silver nitrate. The raw and sand-coated Ag nanoparticle samples were analyzed using various techniques, includi...
Bioactivity and chemical screening of endophytic fungi associated with seaweeds Gracilaria sp. and Sargassum sp. of the Bay of Bengal, Bangladesh.
Scientific reports
May 8, 2025
This study explored the great potential of endophytic fungi associated with red seaweed Gracilaria sp. and brown seaweed Sargassum sp. of the Bay of Bengal, Bangladesh, for the first time. Endophytic fungi were identified taxonomically by morphologic...
Investigating endophytic fungi of Calotropis procera for novel bioactive compounds: molecular docking and bioactivity insights.
Microbial cell factories
May 8, 2025
BACKGROUND: The rising danger of antibiotic resistance and the increasing burden of cancer worldwide have highlighted the necessity for a constant supply of new antimicrobial drugs and anticancer therapies. Endophytic fungi, recognized as a rich supp...
Unveiling Berberine analogues as potential inhibitors of Escherichia coli FtsZ through machine learning molecular docking and molecular dynamics approach.
Scientific reports
Apr 26, 2025
The bacterial cell division protein FtsZ, a crucial GTPase, plays a vital role in the formation of the contractile Z-ring, which is essential for bacterial cytokinesis. Consequently, inhibiting FtsZ could prevent the formation of proto-filaments and ...
Performance and hypothetical clinical impact of an mNGS-based machine learning model for antimicrobial susceptibility prediction of five ESKAPEE bacteria.
Microbiology spectrum
Apr 17, 2025
UNLABELLED: Antimicrobial resistance is an escalating global health crisis, underscoring the urgent need for timely and targeted therapies to ensure effective clinical treatment. We developed a machine learning model based on metagenomic next-generat...
Investigating long-term risk of aortic aneurysm and dissection from fluoroquinolones and the key contributing factors using machine learning methods.
Scientific reports
Apr 16, 2025
The connection between fluoroquinolones and severe heart conditions, such as aortic aneurysm (AA) and aortic dissection (AD), has been acknowledged, but the full extent of long-term risks remains uncertain. Addressing this knowledge deficit, a retros...
Barriers to the widespread adoption of diagnostic artificial intelligence for preventing antimicrobial resistance.
Scientific reports
Apr 16, 2025
Currently, antimicrobial resistance (AMR) poses a major public health challenge. The emergence of AMR, which significantly threatens public health, is primarily due to the overuse of antimicrobial agents. This study explored the possibility that the ...
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