AIMC Topic: Anti-Bacterial Agents

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Antimicrobial and synergistic activity of thiazoline derivatives in combination with conventional antibiotics against multidrug resistant Staphylococcus aureus isolated from abscess drainage samples.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
Emergence and spread of multidrug resistant (MDR) Staphylococcus aureus strains is becoming major challenge in treatment of soft tissue infections. This study aimed to explore antimicrobial and synergistic antimicrobial potential of three commerciall...
Staphylococcus aureus Humans Abscess Drainage Anti-Bacterial Agents Disk Diffusion Antimicrobial Tests Staphylococcal Infections Ribotyping Drug Resistance, Multiple, Bacterial Drug Therapy, Combination Drug Synergism Thiazoles Thiazolidines
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Anti-inflammatory and antibacterial activities of P. petiolosa (Christ) Ching ethyl acetate extract against S. aureus in mice.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
P. petiolosa as a typical Chinese herbal medicine has been generally utilized as Chinese native medicine formulation for treatment of chronic bronchitis, bronchial asthma and pneumoconiosis. The objective of this study was to evaluate the anti-inflam...
Nitric Oxide Synthase Type II Plant Extracts Pneumonia, Staphylococcal Membrane Proteins Polypodiaceae Staphylococcus aureus Anti-Bacterial Agents Disease Models, Animal Mice, Inbred BALB C Tumor Necrosis Factor-alpha Plant Leaves Animals Anti-Inflammatory Agents Solvents Lung Acetates Bacterial Load Heme Oxygenase-1 Inflammation Mediators
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Comparative study of antibacterial activity between Schiff base nicotinic hydrazide derivative and its silver architected nanoparticles with atomic force microscopic study of bacterial cell wall.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
The threat of multi-drug resistant bacterial pathogens evokes researchers to synthesized safe and effective chemotherapeutic agents for nano-drug delivery system. In current study, Schiff base of nicotinic hydrazide(NHD) and its silver nanoparticles(...
Disk Diffusion Antimicrobial Tests Drug Compounding 3T3 Cells Cell Wall Hydrazines Microscopy, Atomic Force Nicotinic Acids Salmonella enterica Anti-Bacterial Agents Animals Schiff Bases Mice Silver Compounds Metal Nanoparticles
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Using Machine Learning Algorithms to Predict Antimicrobial Resistance and Assist Empirical Treatment.

Studies in health technology and informatics Jun 26, 2020
Multi-drug-resistant (MDR) infections and their devastating consequences constitute a global problem and a constant threat to public health with immense costs for their treatment. Early identification of the pathogen and its antibiotic resistance pro...
Machine Learning Anti-Bacterial Agents Drug Resistance, Bacterial Microbial Sensitivity Tests Humans
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Enzyme-powered Janus platelet cell robots for active and targeted drug delivery.

Science robotics Jun 10, 2020
Transforming natural cells into functional biocompatible robots capable of active movement is expected to enhance the functions of the cells and revolutionize the development of synthetic micromotors. However, present cell-based micromotor systems co...
Models, Molecular Equipment Design Urease Motion Cell Line, Tumor Escherichia coli Robotics Blood Platelets Enzymes, Immobilized Multifunctional Nanoparticles Humans Anti-Bacterial Agents Drug Delivery Systems Antineoplastic Agents
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A Deep Learning Approach to Antibiotic Discovery.

Cell Feb 20, 2020
Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed pr...
Machine Learning Anti-Bacterial Agents Animals Clostridioides difficile Mice, Inbred C57BL Small Molecule Libraries Mycobacterium tuberculosis Drug Discovery Cheminformatics Acinetobacter baumannii Mice Thiadiazoles Databases, Chemical Mice, Inbred BALB C
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Studies for Bacterystic Evaluation against of 2-Naphthoic Acid Analogues.

Current topics in medicinal chemistry Jan 1, 2020
BACKGROUND: Staphylococcus aureus is a gram-positive spherical bacterium commonly present in nasal fossae and in the skin of healthy people; however, in high quantities, it can lead to complications that compromise health. The pathologies involved in...
Machine Learning Anti-Bacterial Agents Microbial Sensitivity Tests Naphthalenes Staphylococcus aureus Models, Molecular Molecular Structure Drug Evaluation, Preclinical
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Rumex dentatus could be a potent alternative to treatment of microbial infections and of breast cancer.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Dec 1, 2019
OBJECTIVE: To investigate the phytochemicals and in vitro antioxidant, antimicrobial and cytotoxic potential of Rumex dentatus (R. dentatus) leaf extracts.
Cell Line, Tumor Plant Extracts Bacterial Infections Rumex Humans Anti-Bacterial Agents Breast Neoplasms Antineoplastic Agents
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Phytochemical screening, antioxidant and antibacterial properties of daphne mucronata.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Dec 1, 2019
OBJECTIVE: To aim at preliminary phytochemical screening of Daphne mucronata and evaluate its antioxidant and antibacterial activities.
Phytochemicals Daphne Anti-Bacterial Agents Microbial Sensitivity Tests Antioxidants Staphylococcus aureus
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Assessing clinical heterogeneity in sepsis through treatment patterns and machine learning.

Journal of the American Medical Informatics Association : JAMIA Dec 1, 2019
OBJECTIVE: To use unsupervised topic modeling to evaluate heterogeneity in sepsis treatment patterns contained within granular data of electronic health records.
Quality of Health Care Hospital Mortality Unsupervised Machine Learning Patient Acuity Hospitalization Aged Aged, 80 and over Adult Male Middle Aged Sepsis Anti-Bacterial Agents Retrospective Studies Electronic Health Records Female Humans
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