AIMC Topic: Antineoplastic Agents
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Current Advances and Limitations of Deep Learning in Anticancer Drug Sensitivity Prediction.
Current topics in medicinal chemistry
Jan 1, 2020
Anticancer drug screening can accelerate drug discovery to save the lives of cancer patients, but cancer heterogeneity makes this screening challenging. The prediction of anticancer drug sensitivity is useful for anticancer drug development and the i...
Evolution of Machine Learning Algorithms in the Prediction and Design of Anticancer Peptides.
Current protein & peptide science
Jan 1, 2020
Peptides act as promising anticancer agents due to their ease of synthesis and modifications, enhanced tumor penetration, and less systemic toxicity. However, only limited success has been achieved so far, as experimental design and synthesis of anti...
Rumex dentatus could be a potent alternative to treatment of microbial infections and of breast cancer.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
Dec 1, 2019
OBJECTIVE: To investigate the phytochemicals and in vitro antioxidant, antimicrobial and cytotoxic potential of Rumex dentatus (R. dentatus) leaf extracts.
[Rectal Gastrointestinal Stromal Tumor(GIST)Excised by Two Teams Following Neoadjuvant Chemotherapy-A Case Report].
Gan to kagaku ryoho. Cancer & chemotherapy
Dec 1, 2019
A 67-year-old man presented with bloody stools. Colonoscopy showed a small submucosal tumor in the lower rectum. As the tumor was small, follow-up was chosen. Although he was instructed to undergo reexamination 1 year later, he did not comply. Four y...
Effects of Jiazhu decoction in combination with cyclophosphamide on breast cancer in mice.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
Oct 1, 2019
OBJECTIVE: To investigate the therapeutic effects of Jiazhu decoction (JZD) in combination with cyclophosphamide (CTX) on the growth of breast cancer in mice and to explore the possible molecular mechanisms of action.
[French ccAFU guidelines – Update 2018–2020: Bladder cancer].
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie
Sep 20, 2019
OBJECTIVE: To propose updated French guidelines for non-muscle invasive (NMIBC) and muscle-invasive (MIBC) bladder cancers.
Prediction of Drug Approval After Phase I Clinical Trials in Oncology: RESOLVED2.
JCO clinical cancer informatics
Sep 1, 2019
PURPOSE: Drug development in oncology currently is facing a conjunction of an increasing number of antineoplastic agents (ANAs) candidate for phase I clinical trials (P1CTs) and an important attrition rate for final approval. We aimed to develop a ma...
MOLI: multi-omics late integration with deep neural networks for drug response prediction.
Bioinformatics (Oxford, England)
Jul 15, 2019
MOTIVATION: Historically, gene expression has been shown to be the most informative data for drug response prediction. Recent evidence suggests that integrating additional omics can improve the prediction accuracy which raises the question of how to ...
A deep learning model based on sparse auto-encoder for prioritizing cancer-related genes and drug target combinations.
Carcinogenesis
Jul 4, 2019
Prioritization of cancer-related genes from gene expression profiles and proteomic data is vital to improve the targeted therapies research. Although computational approaches have been complementing high-throughput biological experiments on the under...
A novel machine learning-derived decision tree including uPA/PAI-1 for breast cancer care.
Clinical chemistry and laboratory medicine
May 27, 2019
Background uPA and PAI-1 are breast cancer biomarkers that evaluate the benefit of chemotherapy (CT) for HER2-negative, estrogen receptor-positive, low or intermediate grade patients. Our objectives were to observe clinical routine use of uPA/PAI-1 a...
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