AIMC Topic: Antineoplastic Combined Chemotherapy Protocols

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Computational prediction of multidisciplinary team decision-making for adjuvant breast cancer drug therapies: a machine learning approach.

BMC cancer Dec 1, 2016
BACKGROUND: Multidisciplinary team (MDT) meetings are used to optimise expert decision-making about treatment options, but such expertise is not digitally transferable between centres. To help standardise medical decision-making, we developed a machi...
Female Aged Aged, 80 and over Adult Breast Neoplasms Middle Aged Humans Machine Learning Algorithms Computer Simulation Clinical Decision-Making Patient Care Team Models, Theoretical Antineoplastic Combined Chemotherapy Protocols Combined Modality Therapy Supervised Machine Learning Chemotherapy, Adjuvant
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Efficacy according to blind independent central review: Post-hoc analyses from the phase III, randomized, multicenter, IPASS study of first-line gefitinib versus carboplatin/paclitaxel in Asian patients with EGFR mutation-positive advanced NSCLC.

Lung cancer (Amsterdam, Netherlands) Nov 30, 2016
OBJECTIVE: The Phase III, randomized, open-label IPASS study (NCT00322452) of first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) gefitinib versus carboplatin/paclitaxel for Asian patients with advanced non-small-cell lun...
Gefitinib Quinazolines Carcinoma, Non-Small-Cell Lung Middle Aged Randomized Controlled Trials as Topic Humans Antineoplastic Agents Neoplasm Staging Female Lung Neoplasms Mutation Aged Antineoplastic Combined Chemotherapy Protocols Asian People Aged, 80 and over Adenocarcinoma Carboplatin Male Paclitaxel Disease-Free Survival Smoking ErbB Receptors Protein Kinase Inhibitors
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Machine learning-based classification of diffuse large B-cell lymphoma patients by eight gene expression profiles.

Cancer medicine Feb 11, 2016
Gene expression profiling (GEP) had divided the diffuse large B-cell lymphoma (DLBCL) into molecular subgroups: germinal center B-cell like (GCB), activated B-cell like (ABC), and unclassified (UC) subtype. However, this classification with prognosti...
Support Vector Machine Databases, Genetic Doxorubicin Survival Analysis Cyclophosphamide Prednisone Rituximab Vincristine Genes, Neoplasm Antibodies, Monoclonal, Murine-Derived Germinal Center Middle Aged Gene Expression Profiling ROC Curve Antineoplastic Combined Chemotherapy Protocols Humans Treatment Outcome Prognosis Female Aged Sensitivity and Specificity Lymphoma, Large B-Cell, Diffuse Male
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Pharmacokinetics and Safety of Elotuzumab Combined With Lenalidomide and Dexamethasone in Patients With Multiple Myeloma and Various Levels of Renal Impairment: Results of a Phase Ib Study.

Clinical lymphoma, myeloma & leukemia Dec 21, 2015
INTRODUCTION: The present study evaluated the pharmacokinetics and safety of elotuzumab, a humanized IgG1 monoclonal antibody against signaling lymphocyte activation molecule-F7, combined with lenalidomide and dexamethasone, in patients with multiple...
Retreatment Aged, 80 and over Adult Male Middle Aged Thalidomide Antineoplastic Combined Chemotherapy Protocols Severity of Illness Index Neoplasm Staging Humans Treatment Outcome Dexamethasone Multiple Myeloma Female Kidney Function Tests Lenalidomide Antibodies, Monoclonal, Humanized Aged Cytogenetic Analysis Kidney Diseases
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Postoperative photodynamic therapy as a new adjuvant treatment after robot-assisted salvage surgery of recurrent squamous cell carcinoma of the base of tongue.

World journal of surgical oncology Jul 16, 2015
BACKGROUND: For patients who remain with involved resection margins after transoral robot-assisted salvage surgery (TORS) for recurrent squamous cell carcinoma (SCC) at the base of tongue (BOT) following primary (chemo)radiotherapy, further adjuvant ...
Antineoplastic Combined Chemotherapy Protocols Robotics Neoplasm Staging Neoplasm Recurrence, Local Tongue Neoplasms Photochemotherapy Salvage Therapy Postoperative Period Humans Chemotherapy, Adjuvant Prognosis Female Carcinoma, Squamous Cell Male Middle Aged
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HemOnc.org: A Collaborative Online Knowledge Platform for Oncology Professionals.

Journal of oncology practice Mar 3, 2015
PURPOSE: Cancer care involves extensive knowledge about numerous chemotherapy drugs and chemotherapy regimens. This information is constantly evolving, and there has been no freely available, comprehensive, centralized repository of chemotherapy info...
Humans Software Neoplasms User-Computer Interface Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Access to Information Knowledge Bases Medical Oncology Computer Graphics Interdisciplinary Communication Cooperative Behavior Databases, Pharmaceutical Drug Information Services
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Machine learning models for predicting chemotherapy-induced adverse drug reactions in colorectal cancer patients.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Sep 1, 2025
BACKGROUND: Chemotherapy-induced adverse drug reactions (ADRs) are common in patients with colorectal cancer. We developed four machine learning models to predict chemotherapy-induced ADRs and assessed the performance. These models leverage high-dime...
Humans Organoplatinum Compounds Camptothecin Machine Learning Leucovorin Female Aged Antineoplastic Combined Chemotherapy Protocols Colorectal Neoplasms Support Vector Machine Male Fluorouracil Middle Aged Drug-Related Side Effects and Adverse Reactions Antineoplastic Agents Capecitabine
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Predicting acute diarrhoea in rectal cancer chemoradiotherapy: Secondary analysis of the phase III ARISTOTLE trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Sep 1, 2025
BACKGROUND: Neoadjuvant chemoradiotherapy is a standard treatment for locally advanced rectal cancer, but acute diarrhoea remains a significant side effect, affecting the completion of chemoradiotherapy treatment.
Humans Female Aged Neoadjuvant Therapy Acute Disease Rectal Neoplasms Capecitabine Chemoradiotherapy Irinotecan Adult Male Middle Aged Diarrhea Antineoplastic Combined Chemotherapy Protocols
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Spatial discovery of pyrotinib overcoming HER2-positive breast cancer resistance by breaking fibroblast-induced immune barriers.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy Sep 1, 2025
BACKGROUND: The TCbHP regimen, consisting of combining docetaxel (T), carboplatin (Cb), trastuzumab (H), and pertuzumab (P), is the preferred neoadjuvant treatment for locally advanced human epidermal growth factor 2 (HER2)-positive breast cancer. Ho...
Humans Female Breast Neoplasms Tumor Microenvironment Cell Line, Tumor Acrylamides T-Lymphocytes, Cytotoxic Aminoquinolines Docetaxel B7-H1 Antigen Drug Resistance, Neoplasm Antineoplastic Combined Chemotherapy Protocols Coculture Techniques Neoadjuvant Therapy Receptor, ErbB-2 Antibodies, Monoclonal, Humanized Trastuzumab Fibroblasts
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A Machine Learning-Based Strategy Predicts Selective and Synergistic Drug Combinations for Relapsed Acute Myeloid Leukemia.

Cancer research Jul 15, 2025
UNLABELLED: Combination therapies are one potential approach to improve the outcomes of patients with relapsed/refractory (R/R) disease. However, comprehensive testing in scarce primary patient material is hampered by the many drug combination possib...
Drug Resistance, Neoplasm Bridged Bicyclo Compounds, Heterocyclic Leukemia, Myeloid, Acute Single-Cell Analysis Antineoplastic Combined Chemotherapy Protocols Humans Neoplasm Recurrence, Local Machine Learning Drug Synergism Precision Medicine Female
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