AIMC Topic: Biofilms

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Mapping dental biofilms: from plaque index through planimetry to volumetric analysis.

Clinical oral investigations
OBJECTIVES: Conventional plaque assessment methods, such as clinical indices and planimetry, rely on plaque-disclosing agents and may overemphasize thin biofilm areas due to plaque thickness variations. This study introduces a digital 3D method to qu...

Magnetic Field-Driven Strategies for Biofilm Disruption: From Iron Oxide Nanoparticles to Adaptive Swarms of Magnetic Microrobots.

ACS nano
Biofilms, structured communities of microbial cells embedded in extracellular polymeric substances, are notorious for their resilience against conventional antimicrobial treatments. They contribute significantly to chronic infections and industrial b...

Design of Highly Potent Antibiofilm, Antimicrobial Peptides Using Explainable Artificial Intelligence.

Journal of chemical information and modeling
Antimicrobial peptides have emerged as a potential alternative to traditional small-molecule antimicrobials. They possess broad-spectrum efficacy and increasingly confront the challenges of bacterial resistance, especially the adaptive resistance of ...

Assessment of ceramic rings and k1 biofilter as carriers in phenol and COD removal using SB-MBBR using machine learning and statistical technique.

Biodegradation
This investigation evaluates the performance of a sequencing batch moving bed biofilm reactor (SB-MBBR) employing Ceramic Rings and K1 biofilters as biofilm carriers for the removal of phenol and chemical oxygen demand (COD) from synthetic landfill l...

The Use of DeepQSAR Models for the Discovery of Peptides with Enhanced Antimicrobial and Antibiofilm Potential.

Journal of chemical information and modeling
Increasing concerns regarding prolonged antibiotic usage have spurred the search for alternative treatments. Antimicrobial peptides (AMPs), first discovered in the 1980s, have exhibited significant potential against a broad range of bacteria. Short-s...

Nordihydroguaiaretic acid (NDGA) exhibits potent anti-biofilm and antimicrobial activity against methicillin-resistant Staphylococcus aureus and Candida albicans.

Phytomedicine : international journal of phytotherapy and phytopharmacology
INTRODUCTION: The global rise of antimicrobial resistance (AMR), particularly among biofilm-forming bacteria and fungi, has created an urgent need for novel therapeutics. Nordihydroguaiaretic acid (NDGA), a plant-derived polyphenolic lignan, has demo...

3D-printed chitosan-starch mesh filled with minocycline-alginate hydrogel for dual anti-Staphylococcus aureus and osteogenic effects.

Carbohydrate polymers
Bone infections, particularly those caused by Staphylococcus aureus, pose clinical challenges due to biofilm formation and association with bone loss. To address this, we developed a three-dimensional (3D) printed hydrogel-based drug delivery device ...

Conversion of ozone into hydroxyl radical by granular activated carbon with and without biofilms: Implications for micropollutant abatement.

Journal of hazardous materials
The transformation of ozone (O) into hydroxyl radical (OH) during the ozonation was evaluated in the presence of granular activated carbon (GAC) and biofilm-covered granular activated carbon (BGAC). While both GAC and BGAC accelerated O decomposition...

Detection of bone infections using Vis-NIR and SWIR hyperspectral imaging coupled with machine learning.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Bone infections, such as fracture-related and periprosthetic joint infections, present significant diagnostic and therapeutic challenges in orthopaedic surgery. Current diagnosic standards rely primarily on tissue cultures of intraoperatively obtaine...

Microrobots for Antibiotic-Resistant Skin Colony Eradication.

ACS applied materials & interfaces
Self-propelled nano- and micromachines have immense potential as autonomous seek-and-act devices in biomedical applications. In this study, we present microrobots constructed with inherently biocompatible materials and propulsion systems tailored to ...