AIMC Topic: Biomarkers

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A six‑gene support vector machine classifier contributes to the diagnosis of pediatric septic shock.

Molecular medicine reports
Septic shock is induced by an uncontrolled inflammatory immune response to pathogens and the survival rate of patients with pediatric septic shock (PSS) is particularly low, with a mortality rate of 25‑50%. The present study explored the mechanisms o...

Enabling Technologies for Personalized and Precision Medicine.

Trends in biotechnology
Individualizing patient treatment is a core objective of the medical field. Reaching this objective has been elusive owing to the complex set of factors contributing to both disease and health; many factors, from genes to proteins, remain unknown in ...

Transfer learning radiomics based on multimodal ultrasound imaging for staging liver fibrosis.

European radiology
OBJECTIVES: To propose a transfer learning (TL) radiomics model that efficiently combines the information from gray scale and elastogram ultrasound images for accurate liver fibrosis grading.

Multi-media biomarkers: Integrating information to improve lead exposure assessment.

Environmental research
Exposure assessment traditionally relies on biomarkers that measure chemical concentrations in individual biological media (i.e., blood, urine, etc.). However, chemicals distribute unevenly among different biological media; thus, each medium provides...

Improved small blob detection in 3D images using jointly constrained deep learning and Hessian analysis.

Scientific reports
Imaging biomarkers are being rapidly developed for early diagnosis and staging of disease. The development of these biomarkers requires advances in both image acquisition and analysis. Detecting and segmenting objects from images are often the first ...

Early Recognition of Burn- and Trauma-Related Acute Kidney Injury: A Pilot Comparison of Machine Learning Techniques.

Scientific reports
Severely burned and non-burned trauma patients are at risk for acute kidney injury (AKI). The study objective was to assess the theoretical performance of artificial intelligence (AI)/machine learning (ML) algorithms to augment AKI recognition using ...

Machine learning as new promising technique for selection of significant features in obese women with type 2 diabetes.

Hormone molecular biology and clinical investigation
Background The global trend of obesity and diabetes is considerable. Recently, the early diagnosis and accurate prediction of type 2 diabetes mellitus (T2DM) patients have been planned to be estimated according to precise and reliable methods, artifi...

An unsupervised learning approach to identify novel signatures of health and disease from multimodal data.

Genome medicine
BACKGROUND: Modern medicine is rapidly moving towards a data-driven paradigm based on comprehensive multimodal health assessments. Integrated analysis of data from different modalities has the potential of uncovering novel biomarkers and disease sign...

Biomarker Localization From Deep Learning Regression Networks.

IEEE transactions on medical imaging
Biomarker estimation methods from medical images have traditionally followed a segment-and-measure strategy. Deep-learning regression networks have changed such a paradigm, enabling the direct estimation of biomarkers in databases where segmentation ...