The application of in vitro diagnostic biosensors for early cancer detection remains challenging due to the insufficient representation by a few molecular biomarkers. Digital biomarkers promise comprehensive disease phenotyping but face constraints o...
Metabolomics : Official journal of the Metabolomic Society
Sep 17, 2025
INTRODUCTION AND OBJECTIVES: Oligoasthenozoospermia, characterized by a low sperm count and impaired progressive motility, significantly contributes to male infertility. This study examines the metabolic disparities between individuals with oligoasth...
BACKGROUND: Bipolar disorder (BD) is a highly recurrent disorder. Early detection, early intervention, and prevention of recurrent bipolar mood symptoms are key to a better prognosis.
Chemical communications (Cambridge, England)
Sep 11, 2025
Extracellular vesicles are lipid bilayer-enclosed nanoparticles that play a crucial role in intercellular communication by transporting bioactive molecules across cells, tissues, and even organisms. Although certain aspects of EV biogenesis, function...
BACKGROUND: Ankylosing spondylitis (AS), a chronic inflammatory disorder affecting axial joints, is frequently complicated by uveitis. However, the molecular mechanisms linking AS to secondary uveitis remain poorly understood.
Crohn's disease (CD) is a chronic inflammatory bowel condition that significantly impairs patients' quality of life. With no cure currently available, the need to discover novel biomarkers and develop effective therapeutic strategies is paramount. Th...
In the event of a large-scale radiological or nuclear emergency, a rapid, high-throughput screening tool will be essential for efficient triage of potentially exposed individuals, optimizing scarce medical resources and ensuring timely care. The obje...
Sweat, a biofluid rich in various biomarkers, offers significant potential for non-invasive health monitoring and disease screening. Colorimetric detection is well-suited for multi-analyte quantification and point-of-care testing in sweat analysis, w...
The development of sensors for monitoring breath acetone, a key biomarker for ketosis in diabetes mellitus, represents a critical frontier in medical diagnostics, promising a painless alternative to invasive blood tests. This review provides a compre...
BACKGROUND: Protein lactylation has been implicated in stress-responsive cellular mechanisms, yet its role in lung transplantation-associated ischemia-reperfusion injury (IRI) remains undefined.
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