AIMC Topic: Bone Neoplasms

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LncRNAs regulates cell death in osteosarcoma.

Scientific reports Jul 2, 2025
Despite improvements, prognosis in osteosarcoma patients remains poor, making it essential to identify additional and more robust therapeutic targets. Non-apoptotic receptor-mediated cell death (RCD), which plays a crucial role in the pathogenesis of...
Necroptosis Pyroptosis Cell Death Female Male Gene Expression Profiling Gene Expression Regulation, Neoplastic Osteosarcoma Bone Neoplasms Ferroptosis RNA, Long Noncoding Humans Prognosis
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Automated classification of chondroid tumor using 3D U-Net and radiomics with deep features.

Scientific reports Jul 1, 2025
Classifying chondroid tumors is an essential step for effective treatment planning. Recently, with the advances in computer-aided diagnosis and the increasing availability of medical imaging data, automated tumor classification using deep learning sh...
Humans Machine Learning Tomography, X-Ray Computed Female Deep Learning Imaging, Three-Dimensional Bone Neoplasms Chondroma Adult Radiomics Male Middle Aged
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Synthesizing [F]PSMA-1007 PET bone images from CT images with GAN for early detection of prostate cancer bone metastases: a pilot validation study.

BMC cancer May 21, 2025
BACKGROUND: [F]FDG PET/CT scan combined with [F]PSMA-1007 PET/CT scan is commonly conducted for detecting bone metastases in prostate cancer (PCa). However, it is expensive and may expose patients to more radiation hazards. This study explores deep l...
Bone Neoplasms Positron Emission Tomography Computed Tomography Prostatic Neoplasms Radiopharmaceuticals Deep Learning Pilot Projects Early Detection of Cancer Fluorine Radioisotopes Oligopeptides Niacinamide Humans Retrospective Studies Aged Male Middle Aged
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Surgical and radiological outcomes of giant cell tumor of the bone: prognostic value of Campanacci grading and selective use of denosumab.

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology May 3, 2025
BACKGROUND: Advancements in diagnostic and therapeutic modalities for giant cell tumors of bone (GCTB) have introduced molecular and radiological tools that refine clinical decision-making. H3.3 G34W immunohistochemical staining has become a routine ...
Middle Aged Giant Cell Tumor of Bone Female Bone Neoplasms Mutation Young Adult Humans Curettage Neoplasm Grading Denosumab Adult Prognosis Bone Density Conservation Agents Male Retrospective Studies Histones
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Prediction of High-Dose Methotrexate Blood Concentration in Osteosarcoma Patients Using Machine Learning.

Drug design, development and therapy May 3, 2025
INTRODUCTION: High-dose methotrexate is a typical chemotherapy that is widely used in the treatment of osteosarcoma. However, the unique dose-response relationship of methotrexate makes its treatment window relatively narrow, and its clinical use is ...
Antimetabolites, Antineoplastic Machine Learning Female Young Adult Adult Dose-Response Relationship, Drug Osteosarcoma Humans Bone Neoplasms Male Methotrexate Middle Aged Adolescent Child
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Comparison of CNNs and Transformer Models in Diagnosing Bone Metastases in Bone Scans Using Grad-CAM.

Clinical nuclear medicine Apr 16, 2025
PURPOSE: Convolutional neural networks (CNNs) have been studied for detecting bone metastases on bone scans; however, the application of ConvNeXt and transformer models has not yet been explored. This study aims to evaluate the performance of various...
Neural Networks, Computer Retrospective Studies Female Aged Humans Bone Neoplasms Bone and Bones Male Middle Aged Image Processing, Computer-Assisted
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Identification and validation of HOXC6 as a diagnostic biomarker for Ewing sarcoma: insights from machine learning algorithms and experiments.

Frontiers in immunology Apr 4, 2025
INTRODUCTION: Early diagnosis of Ewing sarcoma (ES) is critical for improving patient prognosis. However, the accurate diagnosis of ES remains challenging, underscoring the need for novel diagnostic biomarkers to enhance diagnostic precision and reli...
Gene Expression Regulation, Neoplastic Cell Proliferation Cell Movement Bone Neoplasms Homeodomain Proteins Sarcoma, Ewing Reproducibility of Results Biomarkers, Tumor Humans Gene Expression Profiling Machine Learning Cell Line, Tumor
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Improved gated recurrent unit-based osteosarcoma prediction on histology images: a meta-heuristic-oriented optimization concept.

Scientific reports Apr 1, 2025
The major prevalent primary bone cancer is osteosarcoma. Preoperative chemotherapy is accompanied by resection as part of the normal course of treatment. The diagnosis and treatment of patients are based on the chemotherapy reaction. Contrarily, chem...
Bone Neoplasms Discriminant Analysis Algorithms Deep Learning Image Processing, Computer-Assisted Osteosarcoma Humans
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A deep learning model for classification of chondroid tumors on CT images.

BMC cancer Mar 28, 2025
BACKGROUND: Differentiating chondroid tumors is crucial for proper patient management. This study aimed to develop a deep learning model (DLM) for classifying enchondromas, atypical cartilaginous tumors (ACT), and high-grade chondrosarcomas using CT ...
Humans Deep Learning Bone Neoplasms Diagnosis, Differential Aged Chondroma Retrospective Studies Chondrosarcoma Adult Tomography, X-Ray Computed Female Male Middle Aged
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AI in radiological imaging of soft-tissue and bone tumours: a systematic review evaluating against CLAIM and FUTURE-AI guidelines.

EBioMedicine Mar 20, 2025
BACKGROUND: Soft-tissue and bone tumours (STBT) are rare, diagnostically challenging lesions with variable clinical behaviours and treatment approaches. This systematic review aims to provide an overview of Artificial Intelligence (AI) methods using ...
Soft Tissue Neoplasms Practice Guidelines as Topic Humans Artificial Intelligence Bone Neoplasms
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