AIMC Topic: Cell Survival
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Synthesis and characterization of Zinc oxide nanoparticles utilizing seed source of Ricinus communis and study of its antioxidant, antifungal and anticancer activity.
Materials science & engineering. C, Materials for biological applications
Dec 10, 2018
ZnO nanoparticles have been synthesized using solution combustion technique and its antioxidant, antifungal, anticancer activity was studied. Ricinus communis plant seed extract used as fuel in synthesis by the solution combustion technique. Powder X...
Aspergillus
Antifungal Agents
Metal Nanoparticles
Zinc Oxide
Spectroscopy, Fourier Transform Infrared
Seeds
Cell Survival
Particle Size
Ricinus
X-Ray Diffraction
Green Chemistry Technology
Microscopy, Electron, Transmission
Microbial Sensitivity Tests
Penicillium
Cell Line, Tumor
Antioxidants
Humans
Plant Extracts
Antineoplastic Agents
Protective effect of polysaccharide from Sophora japonica L. flower buds against UVB radiation in a human keratinocyte cell line (HaCaT cells).
Journal of photochemistry and photobiology. B, Biology
Dec 5, 2018
Natured botanical extract has attracted considerable attention recently in the field of skin anti-ultraviolet (UV) radiation. As a medicinal herb, Sophora japonica flower buds contained several components such as flavonoids, isoflavonoids, triterpene...
Preliminary study on alginate/NIPAM hydrogel-based soft microrobot for controlled drug delivery using electromagnetic actuation and near-infrared stimulus.
Biomedical microdevices
Nov 16, 2018
Currently, microrobots are receiving attention because of their small size and motility, which can be applied to minimal invasive therapy. Additionally, various microrobots using hydrogel with the characteristics of biocompatibility and biodegradabil...
The antifibrotic effect of isolate tagitinin C from tithonia diversifolia (Hemsley) A. Gray on keloid fibroblast cell.
The Pan African medical journal
Aug 8, 2018
INTRODUCTION: Keloids characterized by fibroblast hyperproliferation and depositions of collagen which similar to cancer cells. Tagitinin C is a class of sesquiterpene lactones (SLS) was isolated from the leaves of the moon flower (Hemsley) A. Gray....
Drug response prediction by ensemble learning and drug-induced gene expression signatures.
Genomics
Jul 6, 2018
Chemotherapeutic response of cancer cells to a given compound is one of the most fundamental information one requires to design anti-cancer drugs. Recently, considerable amount of drug-induced gene expression data has become publicly available, in ad...
Building predictive in vitro pulmonary toxicity assays using high-throughput imaging and artificial intelligence.
Archives of toxicology
Apr 28, 2018
Human lungs are susceptible to the toxicity induced by soluble xenobiotics. However, the direct cellular effects of many pulmonotoxic chemicals are not always clear, and thus, a general in vitro assay for testing pulmonotoxicity applicable to a wide ...
Robotic Patterning a Superhydrophobic Surface for Collective Cell Migration Screening.
Tissue engineering. Part C, Methods
Mar 27, 2018
Collective cell migration, in which cells migrate as a group, is fundamental in many biological and pathological processes. There is increasing interest in studying the collective cell migration in high throughput. Cell scratching, insertion blocker,...
ANTENNA, a Multi-Rank, Multi-Layered Recommender System for Inferring Reliable Drug-Gene-Disease Associations: Repurposing Diazoxide as a Targeted Anti-Cancer Therapy.
IEEE/ACM transactions on computational biology and bioinformatics
Mar 16, 2018
Existing drug discovery processes follow a reductionist model of "one-drug-one-gene-one-disease," which is inadequate to tackle complex diseases involving multiple malfunctioned genes. The availability of big omics data offers opportunities to transf...
A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells.
Scientific reports
Feb 28, 2018
AMPK is a serine threonine kinase composed of a heterotrimer of a catalytic, kinase-containing α and regulatory β and γ subunits. Here we show that individual AMPK subunit expression and requirement for survival varies across colon cancer cell lines....
Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase.
Clinical pharmacology and therapeutics
Feb 2, 2018
Deleterious variants in dihydropyrimidine dehydrogenase (DPD, DPYD gene) can be highly predictive of clinical toxicity to the widely prescribed chemotherapeutic 5-fluorouracil (5-FU). However, there are very limited data pertaining to the functional ...
Pharmacogenomic Variants
Inhibitory Concentration 50
HCT116 Cells
HEK293 Cells
Gene Frequency
Mutation, Missense
Dihydrouracil Dehydrogenase (NADP)
Pharmacogenomic Testing
Protein Conformation
Antimetabolites, Antineoplastic
Predictive Value of Tests
Structure-Activity Relationship
Models, Molecular
Machine Learning
Fluorouracil
Pharmacogenetics
Computer Simulation
Genotype
Risk Assessment
Dose-Response Relationship, Drug
Humans
Cell Survival
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