AIMC Topic: Cells, Cultured

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Deep Convolutional and Recurrent Neural Networks for Cell Motility Discrimination and Prediction.

IEEE/ACM transactions on computational biology and bioinformatics Apr 8, 2021
Cells in culture display diverse motility behaviors that may reflect differences in cell state and function, providing motivation to discriminate between different motility behaviors. Current methods to do so rely upon manual feature engineering. How...
Deep Learning Mice Computational Biology Cell Movement Neural Networks, Computer Cells, Cultured Animals Time-Lapse Imaging
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A Cascade of 2.5D CNN and Bidirectional CLSTM Network for Mitotic Cell Detection in 4D Microscopy Image.

IEEE/ACM transactions on computational biology and bioinformatics Apr 6, 2021
Mitosis detection is one of the challenging steps in biomedical imaging research, which can be used to observe the cell behavior. Most of the already existing methods that are applied in detecting mitosis usually contain many nonmitotic events (norma...
Deep Learning Imaging, Three-Dimensional Microscopy Mitosis Humans Neural Networks, Computer Cells, Cultured
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Label-free quality control and identification of human keratinocyte stem cells by deep learning-based automated cell tracking.

Stem cells (Dayton, Ohio) Mar 30, 2021
Stem cell-based products have clinical and industrial applications. Thus, there is a need to develop quality control methods to standardize stem cell manufacturing. Here, we report a deep learning-based automated cell tracking (DeepACT) technology fo...
Stem Cells Cell Differentiation Keratinocytes Quality Control Humans Cells, Cultured Deep Learning Cell Tracking Epidermal Cells
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Expanding the drug discovery space with predicted metabolite-target interactions.

Communications biology Mar 5, 2021
Metabolites produced in the human gut are known modulators of host immunity. However, large-scale identification of metabolite-host receptor interactions remains a daunting challenge. Here, we employed computational approaches to identify 983 potenti...
Cells, Cultured Databases, Factual Inflammatory Bowel Diseases Drug Discovery Humans Machine Learning Metabolome Bacteria Anti-Inflammatory Agents Signal Transduction Gastrointestinal Agents Gastrointestinal Microbiome Data Mining Metabolomics Ligands Gene Expression Profiling Molecular Targeted Therapy Transcriptome Host-Pathogen Interactions Protein Interaction Maps
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Development of Human iPSC-Derived Functional Neuronal Networks on Laser-Fabricated 3D Scaffolds.

ACS applied materials & interfaces Feb 9, 2021
Neural progenitor cells generated from human induced pluripotent stem cells (hiPSCs) are the forefront of ″brain-on-chip″ investigations. Viable and functional hiPSC-derived neuronal networks are shaping powerful models for evaluating the normal and...
Humans Neural Networks, Computer Cells, Cultured Lasers Cell Culture Techniques Induced Pluripotent Stem Cells
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Application of convolutional neural network on early human embryo segmentation during in vitro fertilization.

Journal of cellular and molecular medicine Jan 24, 2021
Selection of the best quality embryo is the key for a faithful implantation in in vitro fertilization (IVF) practice. However, the process of evaluating numerous images captured by time-lapse imaging (TLI) system is time-consuming and some important ...
Fertilization in Vitro Models, Biological Embryo, Mammalian Embryonic Development Cell Culture Techniques Time-Lapse Imaging Neural Networks, Computer Cells, Cultured Pregnancy Female Humans
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Machine learning based CRISPR gRNA design for therapeutic exon skipping.

PLoS computational biology Jan 8, 2021
Restoring gene function by the induced skipping of deleterious exons has been shown to be effective for treating genetic disorders. However, many of the clinically successful therapies for exon skipping are transient oligonucleotide-based treatments ...
Humans Gene Library Exons Embryonic Stem Cells RNA, Guide, CRISPR-Cas Systems Mice CRISPR-Cas Systems Gene Editing Genetic Therapy Machine Learning Cells, Cultured Animals
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Magnetically actuated intelligent hydrogel-based child-parent microrobots for targeted drug delivery.

Journal of materials chemistry. B Jan 5, 2021
Small intestine-targeted drug delivery by oral administration has aroused the growing interest of researchers. In this work, the child-parent microrobot (CPM) as a vehicle protects the child microrobots (CMs) under a gastric acid environment and rele...
Lab-On-A-Chip Devices Magnetic Phenomena Doxorubicin Hydrogels Surface Properties Particle Size Robotics Magnetite Nanoparticles Humans Cells, Cultured Drug Delivery Systems Child
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Characterization of Antiphospholipid Syndrome Atherothrombotic Risk by Unsupervised Integrated Transcriptomic Analyses.

Arteriosclerosis, thrombosis, and vascular biology Dec 24, 2020
OBJECTIVE: Our aim was to characterize distinctive clinical antiphospholipid syndrome phenotypes and identify novel microRNA (miRNA)-mRNA-intracellular signaling regulatory networks in monocytes linked to cardiovascular disease. Approach and Results:...
Unsupervised Machine Learning Risk Assessment Thrombosis Gene Expression Profiling Gene Expression Regulation Risk Factors Transcriptome Oligonucleotide Array Sequence Analysis Adult Case-Control Studies Male Signal Transduction Protein Interaction Maps Middle Aged Cluster Analysis Gene Regulatory Networks MicroRNAs Monocytes Humans Cells, Cultured Antiphospholipid Syndrome Female
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A simple Ca-imaging approach to neural network analyses in cultured neurons.

Journal of neuroscience methods Dec 17, 2020
BACKGROUND: Ca-imaging is a powerful tool to measure neuronal dynamics and network activity. To monitor network-level changes in cultured neurons, neuronal activity is often evoked by electrical or optogenetic stimulation and assessed using multi-ele...
Cells, Cultured Neurons Animals Mice Optogenetics Action Potentials Neural Networks, Computer Algorithms
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