IEEE/ACM transactions on computational biology and bioinformatics
Mar 18, 2019
As one of the most common malignancies in the world, lung adenocarcinoma (LUAD) is currently difficult to cure. However, the advent of precision medicine provides an opportunity to improve the treatment of lung cancer. Subtyping lung cancer plays an ...
Recent advances in large-scale single-cell RNA-seq enable fine-grained characterization of phenotypically distinct cellular states in heterogeneous tissues. We present scScope, a scalable deep-learning-based approach that can accurately and rapidly i...
IEEE transactions on visualization and computer graphics
Mar 15, 2019
Neural embeddings are widely used in language modeling and feature generation with superior computational power. Particularly, neural document embedding - converting texts of variable-length to semantic vector representations - has shown to benefit w...
Protein-peptide interactions play an important role in major cellular processes, and are associated with several human diseases. To understand and potentially regulate these cellular function and diseases it is important to know the molecular details...
Integration of multi-omics in cardiovascular diseases (CVDs) presents high potentials for translational discoveries. By analyzing abundance levels of heterogeneous molecules over time, we may uncover biological interactions and networks that were pre...
Computational intelligence and neuroscience
Mar 3, 2019
At present, research on hesitant fuzzy operations and measures is based on equal length processing, and an equal length processing method will inevitably destroy the original data structure and change the data information. This is an urgent problem t...
In medicine, retinal vessel analysis of fundus images is a prominent task for the screening and diagnosis of various ophthalmological and cardiovascular diseases. In this research, a method is proposed for extracting the retinal blood vessels employi...
Today's audiometric methods for the diagnosis of middle ear disease are often based on a comparison of measurements with standard curves, that represent the statistical range of normal hearing responses. Because of large inter-individual variances in...
Proceedings of the National Academy of Sciences of the United States of America
Feb 26, 2019
A varying oxygen environment is known to affect cellular function in disease as well as activity of various therapeutics. For transient structures, whether they are unconstrained therapeutic transplants, migrating cells during tumor metastasis, or ce...
Transposon insertion sequencing (TIS) is a widely used technique for conducting genome-scale forward genetic screens in bacteria. However, few methods enable comparison of TIS data across multiple replicates of a screen or across independent screens,...