AIMC Topic: Dose-Response Relationship, Drug
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Scaling up drug combination surface prediction.
Briefings in bioinformatics
Mar 4, 2025
Drug combinations are required to treat advanced cancers and other complex diseases. Compared with monotherapy, combination treatments can enhance efficacy and reduce toxicity by lowering the doses of single drugs-and there especially synergistic com...
Non-Linear Dose-Response Relationship for Metformin in Japanese Patients With Type 2 Diabetes: Analysis of Irregular Longitudinal Data by Interpretable Machine Learning Models.
Pharmacology research & perspectives
Feb 1, 2025
The dose-response relationship between metformin and change in hemoglobin A1c (HbA1c) shows a maximum at 1500-2000 mg/day in patients with type 2 diabetes (T2D) in the U.S. In Japan, there is little evidence on the HbA1c-lowering effect of high-dose ...
Integrating real-world data and machine learning: A framework to assess covariate importance in real-world use of alternative intravenous dosing regimens for atezolizumab.
Clinical and translational science
Nov 1, 2024
The increase in the availability of real-world data (RWD), in combination with advances in machine learning (ML) methods, provides a unique opportunity for the integration of the two to explore complex clinical pharmacology questions. Here we present...
Novel predictive approaches for drug-induced convulsions in non-human primates using machine learning and heart rate variability analysis.
The Journal of toxicological sciences
Jan 1, 2024
Drug-induced convulsions are a major challenge to drug development because of the lack of reliable biomarkers. Using machine learning, our previous research indicated the potential use of an index derived from heart rate variability (HRV) analysis in...
Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model.
Journal of enzyme inhibition and medicinal chemistry
Dec 1, 2020
Cyclin-dependent kinase 2 (CDK2) is the family of Ser/Thr protein kinases that has emerged as a highly selective with low toxic cancer therapy target. A multistage virtual screening method combined by SVM, protein-ligand interaction fingerprints (PLI...
Drug Screening Assays, Antitumor
Structure-Activity Relationship
Drug Evaluation, Preclinical
Antineoplastic Agents
A549 Cells
HCT116 Cells
Humans
Cell Proliferation
Molecular Structure
Protein Kinase Inhibitors
Molecular Docking Simulation
Support Vector Machine
Cyclin-Dependent Kinase 2
Dose-Response Relationship, Drug
Formulation and evaluation of antioxidant and antityrosinase activity of Polygonum amplexicaule herbal gel.
Pakistan journal of pharmaceutical sciences
Sep 1, 2020
Medicinal plants are long been used for pharmaceutical and cosmetic industry. Among medicinal plants, Polygonum amplexicaule of family polygonaceae has traditional use in medicines and skin care. P. amplexicaule belongs to genus Polygonum that contai...
Investigating the anti-angiogenic effects of Fufang Kushen Injection in combination with cisplatin using a zebrafish model.
Pakistan journal of pharmaceutical sciences
Sep 1, 2020
The Traditional Chinese Medicine formula Fufang Kushen Injection (FKI) has demonstrated potential to enhance the efficacy and reduce the toxicity of the chemotherapeutic drug cisplatin. However, there is insufficient evidence to determine whether the...
Effects of Plant Species, Insecticide, and Exposure Time On the Efficacy Of Barrier Treatments Against .
Journal of the American Mosquito Control Association
Dec 1, 2018
The effect of 5 plant species (arborvitae [], boxwood [ sp., Japanese honeysuckle [], rhododendron [ sp.], and zebra grass []) and 2 rates of lambda-cyhalothrin (3.13 ml and 6.25 ml active ingredient [AI]/liter) on knockdown (1 h) and mortality (24 h...
In Vitro Investigation of Potential Anti-Diabetic Activity of the Corm Extract of Hypoxis Argentea Harv. Ex Baker.
Acta pharmaceutica (Zagreb, Croatia)
Dec 1, 2018
The corms of Hypoxis argentea are widely used as a traditional remedy for diabetes mellitus in South Africa. In this study, we investigated the effects of non-toxic concentrations (12.5-100 μg mL-1) of the aqueous extract of H. argentea (HAA) corms o...
Acalypha Wilkesiana 'Java White': Identification of Some Bioactive Compounds by Gc-Ms and Their Effects on Key Enzymes Linked to Type 2 Diabete.
Acta pharmaceutica (Zagreb, Croatia)
Dec 1, 2018
In this study, we identified bioactive compounds from the ethanolic extracts of the leaves, stem bark and root bark of Acalypha wilkesiana through GC-MS analysis and investigated the effects of these extracts on some of the enzymes linked to type 2 d...
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