AIMC Topic: Drug Administration Schedule

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Finding medication doses in the liteature.

AMIA ... Annual Symposium proceedings. AMIA Symposium Dec 5, 2018
Medication doses, one of the determining factors in medication safety and effectiveness, are present in the literature, but only in free-text form. We set out to determine if the systems developed for extracting drug prescription information from cli...
Neural Networks, Computer Deep Learning Humans Drug Dosage Calculations Pharmaceutical Preparations Drug Administration Schedule PubMed Drug Administration Routes Information Storage and Retrieval
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Ultrasound-Guided Continuous Thoracic Erector Spinae Plane Block Within an Enhanced Recovery Program Is Associated with Decreased Opioid Consumption and Improved Patient Postoperative Rehabilitation After Open Cardiac Surgery-A Patient-Matched, Controlled Before-and-After Study.

Journal of cardiothoracic and vascular anesthesia Nov 19, 2018
OBJECTIVES: Open cardiac surgery may cause severe postoperative pain. The authors hypothesized that patients receiving a bundle of care using continuous erector spinae plane blocks (ESPB) would have decreased perioperative opioid consumption and impr...
Thoracic Nerves Nerve Block Adult Analgesics, Opioid Follow-Up Studies Cardiac Surgical Procedures Humans Male Dose-Response Relationship, Drug Pain Management Prospective Studies Middle Aged Drug Administration Schedule Postoperative Care Female Adolescent Enhanced Recovery After Surgery Pain, Postoperative Ultrasonography Aged Young Adult
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Ensemble of machine learning algorithms using the stacked generalization approach to estimate the warfarin dose.

PloS one Oct 19, 2018
Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events. Remarkable efforts have been made to develop the machine learning based wa...
Male Middle Aged Pharmacogenetics Cohort Studies Polymorphism, Single Nucleotide Algorithms Databases, Factual Humans Drug Administration Schedule Genotype Linkage Disequilibrium Machine Learning Multivariate Analysis Female Anticoagulants Medical Errors Warfarin Aged International Cooperation Thrombosis Vitamin K Epoxide Reductases Aged, 80 and over Hemorrhage
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Long-term Glomerular Filtration Rate and Kidney Disease: Improving Global Outcomes Stage Stability After Conversion to Once-Daily Tacrolimus in Kidney Transplant Recipients.

Transplantation proceedings Jun 30, 2018
Close monitoring of estimated glomerular filtration rate (eGFR) is important for early recognition of worsening renal function to prevent further deterioration. Safe conversion from twice-daily tacrolimus (TD-Tac) to once-daily tacrolimus (OD-Tac) ha...
Aged Adult Male Middle Aged Glomerular Filtration Rate Humans Cytokines Kidney Transplantation Female Immunosuppressive Agents Tacrolimus Transplant Recipients Drug Administration Schedule
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Reinforcement learning-based control of drug dosing for cancer chemotherapy treatment.

Mathematical biosciences Aug 16, 2017
The increasing threat of cancer to human life and the improvement in survival rate of this disease due to effective treatment has promoted research in various related fields. This research has shaped clinical trials and emphasized the necessity to pr...
Humans Machine Learning Algorithms Computer Simulation Neoplasms Critical Illness Antineoplastic Agents Pregnancy Models, Biological Female Drug Administration Schedule Aged Adult
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Onset of luteolytic action of exogenous prostaglandinF-2α during estrous cycle in goats.

Theriogenology Dec 31, 2016
The objectives of these two experiments were to determine the day of onset of luteolysis after exogenous PGF-2α administration during the estrous cycle and the fertility of this synchronized estrus in goats. In the first experiment, during the breedi...
Female Animals Dinoprost Oxytocics Goats Estrous Cycle Drug Administration Schedule Luteolysis
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Effectiveness of continuous wound infusion of local anesthetics after abdominal surgeries.

The Journal of surgical research Dec 29, 2016
BACKGROUND: To assess the effectiveness of continuous preperitoneal wound infusion of local anesthetic drug bupivacaine in providing pain relief, reducing opioid consumption, and enhancing postoperative recovery.
Pain, Postoperative Bupivacaine Analgesics, Opioid Morphine Drug Therapy, Combination Drug Administration Schedule Infusions, Parenteral Infusions, Intralesional Treatment Outcome Follow-Up Studies Anesthetics, Local Pain Measurement Double-Blind Method Adult Male Prospective Studies Middle Aged Female Adolescent Aged Abdomen Aged, 80 and over Young Adult Humans
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A randomised, phase III trial of once-daily fluticasone furoate/vilanterol 100/25 μg versus once-daily vilanterol 25 μg to evaluate the contribution on lung function of fluticasone furoate in the combination in patients with COPD.

Respiratory medicine Dec 2, 2016
BACKGROUND: The contribution of fluticasone furoate (FF) on lung function in the FF/vilanterol (VI) 100/25 μg combination has been demonstrated numerically, but not statistically.
Androstadienes Adrenergic beta-2 Receptor Agonists Benzyl Alcohols Chlorobenzenes Pulmonary Disease, Chronic Obstructive Humans Male Female Middle Aged Aged Glucocorticoids Drug Administration Schedule Adult Quality of Life Kaplan-Meier Estimate Drug Combinations Administration, Inhalation Double-Blind Method Forced Expiratory Volume
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Effect of Long-Term Hormonal Therapy (vs Short-Term Hormonal Therapy): A Secondary Analysis of Intermediate-Risk Prostate Cancer Patients Treated on NRG Oncology RTOG 9202.

International journal of radiation oncology, biology, physics Nov 8, 2016
PURPOSE: NRG Oncology RTOG 9202 was a randomized trial testing long-term adjuvant androgen deprivation (LTAD) versus initial androgen deprivation only (STAD) with external beam radiation therapy (RT) in mostly high-risk and some intermediate-risk pro...
Radiotherapy, Conformal Drug Administration Schedule Risk Kaplan-Meier Estimate Antineoplastic Agents, Hormonal Middle Aged Time Factors Treatment Outcome Adenocarcinoma Prostatic Neoplasms Prostate-Specific Antigen Neoplasm Grading Androgen Antagonists Combined Modality Therapy Disease-Free Survival Retrospective Studies Aged Aged, 80 and over Survival Rate Male Humans
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The use of natural language processing on narrative medication schedules to compute average weekly dose.

Pharmacoepidemiology and drug safety Sep 16, 2016
PURPOSE: Medications with non-standard dosing and unstandardized units of measurement make the estimation of prescribed dose difficult from pharmacy dispensing data. A natural language processing tool named the SIG extractor was developed to identify...
Humans Reproducibility of Results United States Cyclosporine Natural Language Processing Dose-Response Relationship, Radiation Pharmaceutical Services Confidence Intervals Cyclophosphamide Antirheumatic Agents Drug Administration Schedule United States Department of Veterans Affairs
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