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Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors.
Nature communications
May 23, 2025
Despite the STING-type-I interferon pathway playing a key role in effective anti-tumor immunity, the therapeutic benefit of direct STING agonists appears limited. In this study, we use several artificial intelligence techniques and patient-based mult...
Unlocking the Potential of Wear Time of a Wearable Device to Enhance Postpartum Depression Screening and Detection: Cross-Sectional Study.
JMIR formative research
May 23, 2025
BACKGROUND: Postpartum depression (PPD) is a mood disorder affecting 1 in 7 women after childbirth that is often underscreened and underdetected. If not diagnosed and treated, PPD is associated with long-term developmental challenges in the child and...
Leveraging Digital Twins for Stratification of Patients with Breast Cancer and Treatment Optimization in Geriatric Oncology: Multivariate Clustering Analysis.
JMIR cancer
May 23, 2025
BACKGROUND: Defining optimal adjuvant therapeutic strategies for older adult patients with breast cancer remains a challenge, given that this population is often overlooked and underserved in clinical research and decision-making tools.
Association between fibrinogen levels and prognosis in critically bleeding patients: exploration of the optimal therapeutic threshold.
European journal of trauma and emergency surgery : official publication of the European Trauma Society
May 23, 2025
BACKGROUND: Severe bleeding is a leading cause of ICU admission and mortality. Fibrinogen plays a crucial role in prognosis, yet optimal thresholds and supplementation targets remain unclear.
Needs and Preferences of Swedish Young Adults for a Digital App Promoting Mental Health Literacy, Occupational Balance, and Peer Support: Qualitative Interview Study.
JMIR formative research
May 23, 2025
BACKGROUND: Young adults experience stressors in their transition to adulthood and are at increased risk of mental ill-health. This risk is compounded by young adults' low levels of mental health literacy and limited competencies in implementing stra...
Cost-effectiveness of the 3E model in diabetes management: a machine learning approach to assess long-term economic impact.
Frontiers in public health
May 23, 2025
BACKGROUND: This study investigated the cost-effectiveness and clinical impact of the 3E model (education, empowerment, and economy) in diabetes management using advanced machine learning techniques.
Quantifying the roles of visual, linguistic, and visual-linguistic complexity in noun and verb acquisition.
PloS one
May 23, 2025
Children often learn the meanings of nouns before they grasp the meanings of verbs. This discrepancy could arise from differences in the complexity of visual characteristics for categories that language describes, the inherent structure of language, ...
Construction of a predictive model for relapse of primary autoimmune hemolytic anemia: a retrospective cohort study.
Annals of medicine
May 22, 2025
OBJECTIVES: To develop a machine learning-based model to predict the relapse risk of Primary Autoimmune Haemolytic Anaemia (AIHA) after the last remission.
MRI-based radiomics model for the preoperative prediction of classification in children with venous malformations.
Clinical radiology
May 22, 2025
AIM: This study aimed to explore the efficacy of MRI-based radiomics models, employing various machine learning techniques, in the preoperative prediction of the digital subtraction angiography (DSA) classification of venous malformations (VMs).
Plasma and Urine Circulating Tumor DNA Methylation Profiles for Non-Invasive Pancreatic Ductal Adenocarcinoma Detection: Significant Findings in Plasma Only.
International journal of molecular sciences
May 22, 2025
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with limited treatment options, and early detection remains challenging due to the lack of reliable non-invasive biomarkers. This study investigated plasma and urine circulating tumor deo...
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