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Precision nutrition in epigenetic aging: SHAP-optimized machine learning identifies omega-3 constituent-specific associations with aging biomarkers.

Biogerontology
This cross-sectional investigation seeks to examine the association between dietary omega-3 fatty acids (including α-linolenic acid [ALA], eicosapentaenoic acid [EPA], and docosahexaenoic acid [DHA]) and biomarkers of cellular aging, specifically DNA...

Perceived social support in the daily life of people with Parkinson's disease: a distinct role and potential classifier.

Scientific reports
Motor outcomes in Parkinson's disease (PD) have long been the primary diagnostic criteria and treatment targets. While non-motor outcomes of PD impact daily well-being, they are rarely targeted by interventions or utilized for classification. Despite...

Enhanced HER-2 prediction in breast cancer through synergistic integration of deep learning, ultrasound radiomics, and clinical data.

Scientific reports
This study integrates ultrasound Radiomics with clinical data to enhance the diagnostic accuracy of HER-2 expression status in breast cancer, aiming to provide more reliable treatment strategies for this aggressive disease. We included ultrasound ima...

Detection of breast cancer using machine learning and explainable artificial intelligence.

Scientific reports
Breast cancer is characterized by the proliferation of abnormal breast cells that eventually turn into malignant tumors. These cancer cells can metastasize to be life-threatening and fatal. An intricate mix of environmental factors and individual gen...

A machine learning-based approach to predict depression in Chinese older adults with subjective cognitive decline: a longitudinal study.

Scientific reports
This study aims to identify depressive risks in elderly individuals with subjective cognitive decline (SCD) and develop a predictive model using machine learning algorithms to enable timely interventions.Data from the 2015 and 2018 waves of the China...

Predicting mortality risk in Alzheimer's disease using machine learning based on lifestyle and physical activity.

Scientific reports
Alzheimer's disease (AD), a progressive neurodegenerative disorder, significantly impacts patient survival, prompting the need for accurate prognostic tools. Lifestyle factors and physical activity levels have been identified as critical modifiable r...

A Multi-Modal Pelvic MRI Dataset for Deep Learning-Based Pelvic Organ Segmentation in Endometriosis.

Scientific data
Endometriosis affects approximately 190 million females of reproductive age worldwide. Magnetic Resonance Imaging (MRI) has been recommended as the primary non-invasive diagnostic method for endometriosis. This study presents new female pelvic MRI mu...

Intrahepatic cholestasis of pregnancy.

Nature reviews. Disease primers
Intrahepatic cholestasis of pregnancy is the most common pregnancy-related liver disease, manifesting typically during the third trimester of pregnancy with pruritus and elevated serum bile acids. This condition is associated with increased fetal mor...

Machine-learning driven strategies for adapting immunotherapy in metastatic NSCLC.

Nature communications
Immune checkpoint inhibitors (ICIs), either as monotherapy (ICI-Mono) or combined with chemotherapy (ICI-Chemo), improves survival in advanced non-small cell lung cancer (NSCLC). However, prospective guidance for choosing between these options remain...

Predicting In-Hospital Mortality in Intensive Care Unit Patients Using Causal SurvivalNet With Serum Chloride and Other Causal Factors: Cross-Country Study.

Journal of medical Internet research
BACKGROUND: Incorporating initial serum chloride levels as a prognostic indicator in the intensive care environment has the potential to refine risk stratification and tailor treatment strategies, leading to more efficient use of clinical resources a...