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Mesenchymal stem cell transplantation ameliorates inflammation in spinal cord injury by inhibiting lactylation-related genes.

Cytokine
BACKGROUND: The immune microenvironment significantly influences neural regeneration in spinal cord injury (SCI). Lactate activates central nervous system (CNS) glial cells, prompting the secretion of proinflammatory cytokines and triggering an infla...

Interpretable machine learning models to predict decline in intrinsic capacity among older adults in China: a prospective cohort study.

Maturitas
BACKGROUND: Monitoring intrinsic capacity and implementing appropriate interventions can support healthy aging. There are, though, few tools available for predicting decline in intrinsic capacity among older adults. This study aimed to develop and va...

Genome-wide association study revealed candidate genes associated with egg-laying time traits in layer chicken.

Poultry science
In modern intensive caged laying hen production, variations in egg-laying time (ELT) among layers often increase the workload for egg collection, thereby raising the costs of labor or power and reducing overall efficiency. For management purpose, ear...

Machine Learning Model for Predicting Pheochromocytomas/Paragangliomas Surgery Difficulty: A Retrospective Cohort Study.

Annals of surgical oncology
OBJECTIVE: We aimed to develop a machine learning (ML) model to preoperatively predict surgical difficulty for pheochromocytomas and paragangliomas (PPGLs) using clinical and radiomic features.

Evaluating Algorithmic Approaches to Uncover Racial, Ethnic, and Gender Disparities in Scientific Authorship.

American journal of public health
To explore the capabilities of race/ethnicity and gender prediction algorithms in uncovering patterns of authorship distribution in scientific paper submissions to a major peer-reviewed scientific journal (), we analyzed 17 667 manuscript submissions...

Evaluating natural language processing derived linguistic features associated with current suicidal ideation, past attempts, and future suicidal behavior.

Journal of psychiatric research
BACKGROUND: People with psychosis have a higher suicide risk than the general population. Natural language processing (NLP) has been used to understand communication in psychosis and suicide risk prediction, but not to predict future suicidal behavio...

Development and preliminary testing of a secure large language model-based chatbot for brief alcohol counseling in young adults.

Drug and alcohol dependence
OBJECTIVE: Young adults face elevated risks from alcohol use yet encounter significant barriers to accessing evidence-based interventions. Large language models (LLMs) represent a promising advancement for delivering personalized behavioral intervent...

Multi-task learning for joint prediction of breast cancer histological indicators in dynamic contrast-enhanced magnetic resonance imaging.

Computer methods and programs in biomedicine
OBJECTIVES: Achieving efficient analysis of multiple pathological indicators has great significance for breast cancer prognosis and therapeutic decision-making. In this study, we aim to explore a deep multi-task learning (MTL) framework for collabora...

Deep learning-based auto-contouring of organs/structures-at-risk for pediatric upper abdominal radiotherapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
PURPOSES: This study aimed to develop a computed tomography (CT)-based multi-organ segmentation model for delineating organs-at-risk (OARs) in pediatric upper abdominal tumors and evaluate its robustness across multiple datasets.

An informed machine learning based environmental risk score for hypertension in European adults.

Artificial intelligence in medicine
BACKGROUND: The exposome framework seeks to unravel the cumulated effects of environmental exposures on health. However, existing methods struggle with challenges including multicollinearity, non-linearity and confounding. To address these limitation...