AIMC Topic: Female

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Mechanism of triptolide in the treatment of gastric cancer with diabetes through JAK2/STAT3 pathway.

European journal of pharmacology
Univariate and multivariate Cox analyses revealed a correlation between diabetes and the prognosis of gastric cancer patients (p < 0.05). Using bioinformatics, Serine/threonine-protein kinase pim-1 (PIM1) was identified as the core target gene of tri...

Evaluating the accuracy and patient perception of AI-generated answers on pectus surgery.

Journal of cardiothoracic surgery
UNLABELLED: This article aims to evaluate the quality of responses provided by AI systems ChatGPT-4o and Gemini 1.5 to frequently asked patient questions regarding pectus deformity.

Multi-omics analysis reveal clinical-gut-brain interactions in female ibs patients with adverse childhood experiences.

Biology of sex differences
BACKGROUND: The brain-gut system, which involves bidirectional communication between the central nervous system and the gut, plays a central role in stress responses. Its dysregulation is implicated in irritable bowel syndrome (IBS), a stress-sensiti...

Income, psychological security, and subjective well-being in urban China: a machine learning analysis with SHAP interpretation.

BMC psychology
BACKGROUND: Subjective well-being has become a core indicator for measuring social progress and policy effectiveness. However, the "Easterlin Paradox" remains prevalent, and this paradox refers to the disconnect between economic growth and improvemen...

Association of blood-based DNA methylation of lncRNAs with Alzheimer's disease diagnosis.

Clinical epigenetics
BACKGROUND: DNA methylation has shown great potential in Alzheimer's disease (AD) blood diagnosis. However, the ability of long non-coding RNAs (lncRNAs), which can be modified by DNA methylation, to serve as noninvasive biomarkers for AD diagnosis r...

A macro-micro-macro radiogenomic framework identifies FIBCD1 as a key immune-modulating biomarker in breast cancer.

Journal of translational medicine
BACKGROUND: Breast cancer prognosis remains challenging due to tumor heterogeneity and the limited predictive power of conventional clinical models. Integrating imaging features with molecular data may improve individualized risk stratification and c...

Joint impact of stress hyperglycaemic ratio and glycaemic variability in patients with ischaemic stroke and machine learning for mortality prediction.

BMC neurology
BACKGROUND: The global burden of ischaemic stroke (IS) is high, which is potentially relevant to stress hyperglycemia ratio (SHR) and glycaemic variability (GV). This study aims to evaluate the combined effect of the SHR and GV with predict short-ter...

Cell-free DNA methylation and fragmentomics-based liquid biopsy for accurate esophageal cancer detection.

BMC cancer
BACKGROUND: Cell-free DNA is a promising source of biomarkers for early cancer detection and carries tumor-driven methylation and fragmentation features that have achieved good diagnostic efficacy across various cancers. However, there were no studie...

Machine learning-based clinical-radiomics model for predicting recurrence risk after radical surgery in sinonasal squamous cell carcinoma: a preliminary 2-year follow-up study.

BMC medical imaging
BACKGROUND: To construct and validate an optimal machine learning (ML)-based clinical-radiomics model integrating clinical and radiomics features for predicting recurrence risk within 2 years after radical surgery in patients with sinonasal squamous ...