Analytical methods : advancing methods and applications
Nov 27, 2025
Cellular surface receptors are commonly used as diagnostic and prognostic biomarkers for many infectious diseases. Benchtop clinical instruments, , flow cytometers and fluorescence microscopes are commonly employed for identification and quantificati...
Engineering yeast to secrete target proteins requires searching for optimal combinations of promoters and signal peptides so that genes can be composed that give a high expression and efficient secretion. Most methods for this involve laborious, one-...
Biochemical and biophysical research communications
Aug 6, 2025
Chimeric antigen receptor T (CAR-T)-cell therapy has emerged as a promising treatment for hematologic malignancies. Accurate monitoring of CAR expression levels is essential for optimizing therapeutic efficacy and ensuring patient safety. Conventiona...
Microscopic-Diffraction Imaging Flow Cytometry (MDIFC) is a high-throughput, stain-free technology that captures paired microscopic and diffraction images of cellular events, utilizing machine learning for the classification of cell subpopulations. H...
Aging heterogeneity in tissue-regenerative cells leads to variable therapeutic outcomes, complicating quality control and clinical predictability. Conventional analytical methods relying on labeling or cell lysis are destructive and incompatible with...
Investigating the temporal dynamics of gene expression is crucial for understanding gene regulation across various biological processes. Using the Fluorescent Timer protein, the Timer-of-cell-kinetics-and-activity system enables analysis of transcrip...
Early diagnosis and treatment initiation of chronic myeloid leukemia (CML) are considered to increase the rate of deep molecular response. However, the early diagnosis of CML is challenging due to the absence of clinical symptoms and peripheral blood...
To complement serology as a tool in public health interventions, we introduced the "celluloepidemiology" paradigm where we leveraged pathogen-specific T cell responses at a population level to advance our epidemiological understanding of infectious d...
BACKGROUND: Dental pulp cells-derived small extracellular vesicles (DPCs-sEVs) had shown immunomodulatory, anti-inflammatory, and tissue function restorative abilities. Therefore, DPCs-sEVs should be considered as a promising regenerative tool for de...
OBJECTIVE: This study aimed to perform a detailed stratification analysis of B lymphocyte subsets in patients with primary Sjögren's syndrome (pSS) and to investigate their associations with lymphoma risk, clinical phenotypes, and disease activity.
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.