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Gastrointestinal Microbiome

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Early-life and concurrent predictors of the healthy adolescent microbiome in a cohort study.

Genome medicine
BACKGROUND: The microbiome of adolescents is poorly understood, as are factors influencing its composition. We aimed to describe the healthy adolescent microbiome and identify early-life and concurrent predictors of its composition.

4-Hydroxyboesenbergin B of Alpinia japonica protected gastrointestinal tract by inhibiting vancomycin-resistant enterococcus and balancing intestinal microbiota.

Journal of ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE: Alpinia japonica, a traditional herb utilized in Miao medicine in southwestern China, has been employed to alleviate symptoms such as stomachache, diarrhea, and abdominal pain, some of these symptoms may be associated ...

Machine learning algorithms reveal gut microbiota signatures associated with chronic hepatitis B-related hepatic fibrosis.

World journal of gastroenterology
BACKGROUND: Hepatic fibrosis (HF) represents a pivotal stage in the progression and potential reversal of cirrhosis, underscoring the importance of early identification and therapeutic intervention to modulate disease trajectory.

Unique Microbial Characterisation of Oesophageal Squamous Cell Carcinoma Patients with Different Dietary Habits Based on Light Gradient Boosting Machine Learning Classifier.

Nutrients
: The microbiome plays an important role in cancer, but the relationship between dietary habits and the microbiota in oesophageal squamous cell carcinoma (ESCC) is not clear. The aim of this study is to explore the complex relationship between the mi...

Deciphering Gut Microbiome in Colorectal Cancer via Robust Learning Methods.

Genes
BACKGROUND: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and is closely linked to the gut microbiota. Identifying reproducible and generalizable microbial signatures holds significant potential for enhancing early detection ...

The Influence of an AI-Driven Personalized Nutrition Program on the Human Gut Microbiome and Its Health Implications.

Nutrients
Personalized nutrition programs enhanced with artificial intelligence (AI)-based tools hold promising potential for the development of healthy and sustainable diets and for disease prevention. This study aimed to explore the impact of an AI-based pe...

AI and Machine Learning Computational Modeling that Takes into Consideration Gut Microbiota for a Personalized Decision Support Preoperative Planning for an Optimum Liver Regeneration After Partial Hepatectomy.

Studies in health technology and informatics
INTRODUCTION: Gut microbiota (GM) is implicated in the remnant liver regeneration (LR) after partial hepatectomy (PH) and affects outcomes. Our study shifts the algorithmic computational modeling from the classical knowledge of (LR) to that of (GM) i...

Best practices for developing microbiome-based disease diagnostic classifiers through machine learning.

Gut microbes
The human gut microbiome, crucial in various diseases, can be utilized to develop diagnostic models through machine learning (ML). The specific tools and parameters used in model construction such as data preprocessing, batch effect removal and model...

Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson's disease.

Nature communications
There is strong interest in using the gut microbiome for Parkinson's disease (PD) diagnosis and treatment. However, a consensus on PD-associated microbiome features and a multi-study assessment of their diagnostic value is lacking. Here, we present a...

Learning a deep language model for microbiomes: The power of large scale unlabeled microbiome data.

PLoS computational biology
We use open source human gut microbiome data to learn a microbial "language" model by adapting techniques from Natural Language Processing (NLP). Our microbial "language" model is trained in a self-supervised fashion (i.e., without additional externa...