Journal of cellular and molecular medicine
Jun 1, 2025
Oral cancer is among the most prevalent malignant tumours worldwide; prognosis can be affected by several factors, including molecular subtypes, immune microenvironment and clinical characteristics. In this study, we aimed to apply machine learning m...
BACKGROUND: The relationship between autophagy and the progression of hepatocellular carcinoma (HCC) is notably substantial, yet the underlying mechanisms remain incompletely elucidated. Our objective is to construct a predictive model, thereby provi...
International journal of biological macromolecules
Jun 1, 2025
The pathogenesis of kidney cancer is not fully understood, so there is an urgent need to identify new biomarkers to improve diagnosis and treatment. The study identified KIF4A, TOP2A and ASPM as novel protein biomarkers for renal cancer and explored ...
This study achieved cancer type and survival time prediction by transforming transcriptomic features into feature maps and employing deep learning models. Using transcriptomic data from 27 cancer types and survival data from 10 types in the TCGA data...
Interdisciplinary sciences, computational life sciences
Jun 1, 2025
Existing single-cell clustering methods are based on gene expressions that are susceptible to dropout events in single-cell RNA sequencing (scRNA-seq) data. To overcome this limitation, we proposed a pathway-based clustering method for single cells (...
BACKGROUND: Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide, with late-stage diagnoses frequently leading to poor outcomes. This underscores the need for effective early-stage gastric cancer (ESGC) diagnostics.
Platinum-based therapy is an integral part of the standard treatment for ovarian cancer. However, despite extensive research spanning several decades, the identification of dependable predictive biomarkers for platinum response in clinical practice h...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
May 31, 2025
Anoikis resistance plays a crucial role in the proliferation, metastasis, and invasion of hepatocellular carcinoma (HCC). However, the key genes involved remain to be identified. This study aimed to investigate the prognostic value and impact of anoi...
BACKGROUND: Macrophages are closely associated with the progression of Kidney renal clear cell carcinoma (KIRC) and can influence programmed cell death (PCD) of tumour cells. To identify prognostic biomarkers for KIRC, it is essential to investigate ...
Cancer stem cells (CSCs), distinguished by their abilities to differentiate and self-renew, play a pivotal role in the progression of colorectal cancer (CRC). However, the mechanisms that sustain CSCs in CRC remain unclear. This study aimed to identi...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.