AIMC Topic: Gene Regulatory Networks

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Deciphering the role of metal ion transport-related genes in T2D pathogenesis and immune cell infiltration via scRNA-seq and machine learning.

Frontiers in immunology Jan 24, 2025
INTRODUCTION: Type 2 diabetes (T2D) is a complex metabolic disorder with significant global health implications. Understanding the molecular mechanisms underlying T2D is crucial for developing effective therapeutic strategies. This study employs sing...
Protein Interaction Maps Ion Transport RNA-Seq Gene Regulatory Networks Gene Expression Profiling Humans Diabetes Mellitus, Type 2 Metals Machine Learning Single-Cell Analysis Single-Cell Gene Expression Analysis
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Identification of potential biomarkers for 2022 Mpox virus infection: a transcriptomic network analysis and machine learning approach.

Scientific reports Jan 23, 2025
Monkeypox virus (MPXV), a zoonotic pathogen, re-emerged in 2022 with the Clade IIb variant, raising global health concerns due to its unprecedented spread in non-endemic regions. Recent studies have shown that Clade IIb (2022 MPXV) is marked by uniqu...
Gene Regulatory Networks Computational Biology Mpox, Monkeypox Host-Pathogen Interactions Monkeypox virus Biomarkers Humans Machine Learning Gene Expression Profiling Transcriptome
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Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning.

Frontiers in immunology Jan 23, 2025
BACKGROUND: The etiology of interstitial cystitis/painful bladder syndrome (IC/BPS) remains elusive, presenting significant challenges in both diagnosis and treatment. To address these challenges, we employed a comprehensive approach aimed at identif...
Biomarkers Gene Expression Profiling Transcriptome Gene Regulatory Networks Computational Biology Cystitis, Interstitial Humans Machine Learning
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Palmitoylation-related gene ZDHHC22 as a potential diagnostic and immunomodulatory target in Alzheimer's disease: insights from machine learning analyses and WGCNA.

European journal of medical research Jan 22, 2025
BACKGROUND: The mechanism of palmitoylation in the pathogenesis of Alzheimer's disease (AD) remains unclear.
Acyltransferases Gene Regulatory Networks Alzheimer Disease Lipoylation Machine Learning ROC Curve Humans
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Uncovering glycolysis-driven molecular subtypes in diabetic nephropathy: a WGCNA and machine learning approach for diagnostic precision.

Biology direct Jan 21, 2025
INTRODUCTION: Diabetic nephropathy (DN) is a common diabetes-related complication with unclear underlying pathological mechanisms. Although recent studies have linked glycolysis to various pathological states, its role in DN remains largely underexpl...
Humans Machine Learning Gene Regulatory Networks Diabetic Nephropathies Glycolysis
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Establishment of a nomogram model based on immune-related genes using machine learning for aortic dissection diagnosis and immunomodulation assessment.

International journal of medical sciences Jan 21, 2025
The clinical manifestation of aortic dissection (AD) is complex and varied, making early diagnosis crucial for patient survival. This study aimed to identify immune-related markers to establish a nomogram model for AD diagnosis. Three datasets from G...
Chemokine CXCL1 Tissue Inhibitor of Metalloproteinase-1 Serum Amyloid P-Component Male Gene Expression Profiling C-Reactive Protein Humans Protein Interaction Maps Aortic Dissection Gene Regulatory Networks Machine Learning Immunomodulation Nomograms Databases, Genetic
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Biocomputing at the crossroad between emulating artificial intelligence and cellular supremacy.

Current opinion in biotechnology Jan 20, 2025
Biocomputation aims to create sophisticated biological systems capable of addressing important problems in (bio)medicine with a machine-like precision. At present, computational gene networks engineered by single- or multi-layered assembly of DNA-, R...
Animals Gene Regulatory Networks Computational Biology Humans Artificial Intelligence
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Machine learning-driven identification of critical gene programs and key transcription factors in migraine.

The journal of headache and pain Jan 20, 2025
BACKGROUND: Migraine is a complex neurological disorder characterized by recurrent episodes of severe headaches. Although genetic factors have been implicated, the precise molecular mechanisms, particularly gene expression patterns in migraine-associ...
Genome-Wide Association Study Gene Regulatory Networks Genetic Predisposition to Disease Humans Machine Learning Gene Expression Profiling Migraine Disorders Polymorphism, Single Nucleotide Transcription Factors
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AI-driven automated discovery tools reveal diverse behavioral competencies of biological networks.

eLife Jan 13, 2025
Many applications in biomedicine and synthetic bioengineering rely on understanding, mapping, predicting, and controlling the complex behavior of chemical and genetic networks. The emerging field of diverse intelligence investigates the problem-solvi...
Gene Regulatory Networks Synthetic Biology Artificial Intelligence Algorithms
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The role of mitophagy-related genes in prognosis and immunotherapy of cutaneous melanoma: a comprehensive analysis based on single-cell RNA sequencing and machine learning.

Immunologic research Jan 11, 2025
Mitophagy, the selective degradation of mitochondria by autophagy, plays a crucial role in cancer progression and therapy response. This study aims to elucidate the role of mitophagy-related genes (MRGs) in cutaneous melanoma (CM) through single-cell...
Gene Expression Profiling Transcriptome Single-Cell Analysis Skin Neoplasms Tumor Microenvironment Biomarkers, Tumor Gene Expression Regulation, Neoplastic Melanoma, Cutaneous Malignant Mitophagy Gene Regulatory Networks Immunotherapy Sequence Analysis, RNA Humans Machine Learning Prognosis Melanoma
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