AIMC Topic: Genetic Predisposition to Disease

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Machine learning in cardiovascular medicine: are we there yet?

Heart (British Cardiac Society) Jan 19, 2018
Artificial intelligence (AI) broadly refers to analytical algorithms that iteratively learn from data, allowing computers to find hidden insights without being explicitly programmed where to look. These include a family of operations encompassing sev...
Datasets as Topic Clinical Trials as Topic Cardiology Genetic Predisposition to Disease Causality Diagnostic Imaging Registries Humans Machine Learning Phenotype Big Data Genomics
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Multi-label Deep Learning for Gene Function Annotation in Cancer Pathways.

Scientific reports Jan 10, 2018
The war on cancer is progressing globally but slowly as researchers around the world continue to seek and discover more innovative and effective ways of curing this catastrophic disease. Organizing biological information, representing it, and making ...
Humans Genetic Association Studies Computational Biology Databases, Genetic Molecular Sequence Annotation Machine Learning Algorithms Neoplasms Genetic Predisposition to Disease
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AutismKB 2.0: a knowledgebase for the genetic evidence of autism spectrum disorder.

Database : the journal of biological databases and curation Jan 1, 2018
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with strong genetic contributions. To provide a comprehensive resource for the genetic evidence of ASD, we have updated the Autism KnowledgeBase (AutismKB) to version 2.0. Autism...
Internet Knowledge Bases Molecular Sequence Annotation Humans Autism Spectrum Disorder User-Computer Interface Genetic Predisposition to Disease
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Variants in GNPTAB, GNPTG and NAGPA genes are associated with stutterers.

Gene Dec 28, 2017
Non-syndromic stuttering is a neurodevelopmental disorder characterized by disruptions in normal flow of speech in the form of repetition, prolongation and involuntary halts. Previously, mutations with more severe effects on GNPTAB and GNPTG have bee...
Homozygote Introns Mucolipidoses Humans Phosphoric Diester Hydrolases Stuttering Transferases (Other Substituted Phosphate Groups) Child Genetic Predisposition to Disease Mutation Heterozygote Phenotype Female Male Child, Preschool
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Association of the CYP17 MSP AI (T-34C) and CYP19 codon 39 (Trp/Arg) polymorphisms with susceptibility to acne vulgaris.

Clinical and experimental dermatology Dec 28, 2017
The aim of this study was to detect the association of the cytochrome P450 (CYP) 17 T-34C and CYP19 T
Adult Male Case-Control Studies Adolescent Humans Female Young Adult Acne Vulgaris Aromatase Steroid 17-alpha-Hydroxylase Genetic Predisposition to Disease Genotype Iran Polymorphism, Genetic
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Data Mining and Machine Learning Algorithms Using IL28B Genotype and Biochemical Markers Best Predicted Advanced Liver Fibrosis in Chronic Hepatitis C.

Japanese journal of infectious diseases Dec 26, 2017
IL28B single nucleotide polymorphism (rs12979860) is an etiology-independent predictor of hepatitis C virus (HCV)-related hepatic fibrosis. Data mining is a method of predictive analysis which can explore tremendous volumes of information from health...
Humans Machine Learning Interleukins Genetic Markers Data Mining Hepatitis C, Chronic Interferons Middle Aged Genetic Predisposition to Disease Algorithms Polymorphism, Single Nucleotide Retrospective Studies Liver Cirrhosis Female Male
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Genomic risk prediction of aromatase inhibitor-related arthralgia in patients with breast cancer using a novel machine-learning algorithm.

Cancer medicine Nov 23, 2017
Many breast cancer (BC) patients treated with aromatase inhibitors (AIs) develop aromatase inhibitor-related arthralgia (AIA). Candidate gene studies to identify AIA risk are limited in scope. We evaluated the potential of a novel analytic algorithm ...
Humans Machine Learning Prognosis Genomics Genetic Predisposition to Disease Polymorphism, Single Nucleotide Neoplasm Staging Female Breast Neoplasms Middle Aged Case-Control Studies Aromatase Inhibitors Arthralgia Antineoplastic Agents, Hormonal Germ-Line Mutation
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PSCA rs1045531 Polymorphism and the Risk of Prostate Cancer in a Chinese Population Undergoing Prostate Biopsy.

Technology in cancer research & treatment Nov 14, 2017
BACKGROUND AND PURPOSE: This study explored the association between a single-nucleotide polymorphism of prostate stem cell antigen and prostate cancer in Chinese patients undergoing prostate biopsy.
Genetic Association Studies GPI-Linked Proteins Middle Aged Antigens, Neoplasm Humans Genetic Predisposition to Disease Neoplasm Proteins Risk Factors Prostate-Specific Antigen Polymorphism, Single Nucleotide Prostatic Neoplasms Aged Neoplasm Grading Genotype Male Prostate Biopsy
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Predicting pathogenic genes for primary myelofibrosis based on a system‑network approach.

Molecular medicine reports Oct 20, 2017
The aim of the present study was to predict pathogenic genes for primary myelofibrosis (PMF) using a system‑network approach by combining protein‑protein interaction (PPI) network and gene expression data with known pathogenic genes. PMF gene express...
Primary Myelofibrosis Genetic Association Studies Computational Biology Signal Transduction Models, Biological Humans Neural Networks, Computer Gene Expression Profiling Gene Regulatory Networks Genetic Predisposition to Disease
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Single Nucleotide Polymorphism relevance learning with Random Forests for Type 2 diabetes risk prediction.

Artificial intelligence in medicine Sep 22, 2017
OBJECTIVE: The use of artificial intelligence techniques to find out which Single Nucleotide Polymorphisms (SNPs) promote the development of a disease is one of the features of medical research, as such techniques may potentially aid early diagnosis ...
Decision Support Systems, Clinical Logistic Models Diabetes Mellitus, Type 2 Support Vector Machine Genetic Predisposition to Disease Decision Trees Polymorphism, Single Nucleotide Prognosis Clinical Decision-Making Risk Factors Risk Assessment Humans Decision Support Techniques Phenotype
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