International journal of pharmaceutics
Nov 15, 2025
Transdermal drug delivery systems (TDDS) offer a painless and non-invasive route of administration but are limited by the skin barrier. Microneedles (MNs) have been shown to overcome this challenge and enable the delivery of small molecules, peptides...
Metabolomics : Official journal of the Metabolomic Society
Nov 15, 2025
INTRODUCTION: Identifying the phytochemistry underpinning a plant's observed therapeutic benefits is essential for understanding mechanisms of action and developing novel therapeutics. More recent efforts fusing global metabolomics and multivariate p...
Metabolomics : Official journal of the Metabolomic Society
Nov 15, 2025
INTRODUCTION: Dementia can be prevented through early intervention; hence, there is an urgent need for biomarkers to help diagnose mild cognitive impairment (MCI).
Preeclampsia, characterized by high blood pressure, proteinuria and organ dysfunction in severe cases is a hypertensive disorder that occurs during pregnancy. There is strong evidence that this disease, whose etiology remains unclear, is a complex co...
PURPOSE: To conduct a systematic review of studies examining the use of artificial intelligence (AI) algorithms in predicting the progression of keratoconus (KCN).
UNLABELLED: Prognostic scores such as the Pediatric Index of Mortality (PIM-3) are widely used to estimate mortality risk in PICUs, yet their performance in low- and middle-income countries (LMICs) remains uncertain. We aimed to evaluate the predicti...
Progress in neuro-psychopharmacology & biological psychiatry
Nov 14, 2025
BACKGROUND: Obsessive-compulsive disorder (OCD) is characterized by disruptions in large-scale brain networks. However, the role of high-frequency neural synchrony in these abnormalities remains unclear. Elucidating frequency-specific alterations may...
Accurate toxicity prediction is a critical component of pharmaceutical development and regulatory safety evaluation, traditionally relying on molecular descriptor-based models. This study compares the performance of descriptor-based features (Mordred...
Journal of chemical information and modeling
Nov 14, 2025
Topological data analysis (TDA) has emerged as a powerful framework for extracting robust, multiscale, and interpretable features from complex molecular data for artificial intelligence (AI) modeling and topological deep learning (TDL). This review p...
Proceedings of the National Academy of Sciences of the United States of America
Nov 14, 2025
As AI systems from decision-making algorithms to generative AI are deployed more widely, computer scientists and social scientists alike are being called on to provide trustworthy quantitative evaluations of AI safety and reliability. These calls hav...
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