International journal of molecular medicine
Oct 3, 2025
Emerging evidence indicates a significant association between the composition and functionality of the gut microbiome and various skin disorders, including psoriasis, atopic dermatitis, acne and several dermatological conditions. The gut‑skin axis t...
Diabetic kidney disease (DKD) is a microvascular complication of diabetes that can progress to renal failure. Tert-butylhydroquinone (TBHQ) exhibits renal protective effects in type II diabetes, but its regulatory role on microvascular protection-rel...
In the field of self-powered sensing, the need for wearing comfort and flexibility of the material is increasing. Although piezoelectric ceramics have excellent piezoelectric properties, their poor flexibility limits their application range. In the q...
Proceedings of the National Academy of Sciences of the United States of America
Oct 3, 2025
As climate change makes agricultural production shocks more frequent and severe, it is vital to understand their effect on farmer welfare, land use, and deforestation. Theoretically, a change in agricultural productivity could increase or decrease de...
BACKGROUND: Manual interpretation of copy-number variant (CNV) according to the guideline published by the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resources (ClinGen) in 2020 is labor-intensive and time-consum...
OBJECTIVE: This study aims to develop multiple machine learning models for predicting hypothermia risk in laparoscopic surgery and to perform interpretability analysis of the best-performing model. Our goal is to provide robust decision support for c...
OBJECTIVE: The presence of pancreaticobiliary maljunction (PBM) in pediatric patients with congenital choledochal malformation significantly impacts clinical management and surgical decision-making. Current preoperative evaluation of PBM coexistence ...
BACKGROUNDS: Consensus molecular subtype 4 (CMS4) of colorectal cancer (CRC) is characterized by TGF-β activation, and generally accompanied with metastasis and recurrence. Nevertheless, molecular biomarkers and regulatory mechanisms underlying CMS4 ...
BACKGROUND: There is variability in overall survival among 2021 World Health Organization isocitrate dehydrogenase wild type glioblastoma (IDH-wt GBM) patients. The aim of the study was to develop a combined model for stratifying survival risk in IDH...
BACKGROUND: Single-cell foundation models (scFMs) have emerged as powerful tools for integrating heterogeneous datasets and exploring biological systems. Despite high expectations, their ability to extract unique biological insights beyond standard m...
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