AIMC Topic: Humans

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The tumor immune microenvironment in pancreatic cancer and its potential in the identification of immunotherapy biomarkers.

Expert review of molecular diagnostics
INTRODUCTION: Pancreatic cancer (PC) has an extremely poor prognosis, even with surgical resection and triplet chemotherapy treatment. Cancer immunotherapy has been recently approved for tumor-agnostic treatment with genome analysis, including in PC....

Simulation-based design optimization for statistical power: Utilizing machine learning.

Psychological methods
The planning of adequately powered research designs increasingly goes beyond determining a suitable sample size. More challenging scenarios demand simultaneous tuning of multiple design parameter dimensions and can only be addressed using Monte Carlo...

Integrating machine learning and high throughput screening for the discovery of allosteric AKT1 inhibitors.

Journal of biomolecular structure & dynamics
Evidence from clinical and experimental investigations reveals the role of AKT in oral cancer, which has led to the development of therapeutic and pharmacological medications for inhibiting AKT protein. Despite prodigious effort, researchers are sear...

Development of a dental digital data set for research in artificial intelligence: the importance of labeling performed by radiologists.

Oral surgery, oral medicine, oral pathology and oral radiology
OBJECTIVE: The aim of this study was to present the development of a database (dataset) of panoramic radiographs.

Machine learning-based delta check method for detecting misidentification errors in tumor marker tests.

Clinical chemistry and laboratory medicine
OBJECTIVES: Misidentification errors in tumor marker tests can lead to serious diagnostic and treatment errors. This study aims to develop a method for detecting these errors using a machine learning (ML)-based delta check approach, overcoming limita...

Anti-mutated citrullinated vimentin antibodies are increased in IPF patients.

Respiratory medicine and research
INTRO: An increased prevalence of serum anti-MCV antibody is observed in the serum of patients with idiopathic pulmonary fibrosis (IPF) but the clinical relevance of these antibodies is unknown.

Single port (SP) robotic pyeloplasty in a pediatric patient.

Journal of pediatric urology
We began using the da Vinci single port (SP) robot for pediatric urologic surgeries at our institution due to limited access to the multiport robot. Availability of this technology has allowed us to schedule cases in a timelier fashion and increase a...

Insight into Automatic Image Diagnosis of Ear Conditions Based on Optimized Deep Learning Approach.

Annals of biomedical engineering
Examining otoscopic images for ear diseases is necessary when the clinical diagnosis of ear diseases extracted from the knowledge of otolaryngologists is limited. Improved diagnosis approaches based on otoscopic image processing are urgently needed. ...

Diagnosing and grading gastric atrophy and intestinal metaplasia using semi-supervised deep learning on pathological images: development and validation study.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
OBJECTIVE: Patients with gastric atrophy and intestinal metaplasia (IM) were at risk for gastric cancer, necessitating an accurate risk assessment. We aimed to establish and validate a diagnostic approach for gastric biopsy specimens using deep learn...