AIMC Topic: Humans

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Syllable-based speech characteristics as potential biomarker for differential diagnosis of Parkinson's disease, multiple system atrophy, and cerebellar ataxia.

Journal of neurology
Speech disorders differ between Parkinson's disease (PD) and multiple system atrophy (MSA), but studies focusing on group differences based on syllables or including cerebellar ataxia (CA) are lacking until now. This cross-sectional study aimed to an...

Benchmarking feature projection methods in radiomics.

Scientific reports
In radiomics, feature selection methods are primarily used to eliminate redundant features and identify relevant ones. Feature projection methods, such as principal component analysis (PCA), are often avoided due to concerns that recombining features...

Machine learning for the prediction of blood transfusion risk during or after mitral valve surgery: a multicenter retrospective cohort study.

Scientific reports
This study aimed to identify the optimal prediction method and key preoperative variables for red blood cell (RBC) transfusion risk in patients undergoing mitral valve surgery. We conducted a retrospective study involving 1477 patients from eight lar...

High transposable element expression in sarcomas is associated with increased immune infiltrates and improved outcomes including after immunotherapy.

Journal for immunotherapy of cancer
BACKGROUND: Response to immune checkpoint inhibition (ICI) in sarcomas is overall low and heterogeneous. Understanding determinants of ICI outcomes may improve efficacy and patient selection. Thus, we investigated whether the expression of transposab...

Predictive modelling of clinically significant depressive symptoms after coronary artery bypass graft surgery: protocol for a multicentre observational study in two Swiss hospitals (the PsyCor study).

BMJ open
INTRODUCTION: Coronary artery bypass grafting (CABG) remains one of the most commonly performed cardiac surgeries worldwide. Despite surgical advancements, a significant proportion of patients experience psychological distress following surgery, with...

Implementation of Fully Automated AI-Integrated System for Body Composition Assessment on Computed Tomography for Opportunistic Sarcopenia Screening: Multicenter Prospective Study.

JMIR formative research
BACKGROUND: Opportunistic computed tomography (CT) screening for the evaluation of sarcopenia and myosteatosis has been gaining emphasis. A fully automated artificial intelligence (AI)-integrated system for body composition assessment on CT scans is ...

Nurses' Intention to Integrate AI Into Their Practice: Survey Study in Canada.

JMIR nursing
BACKGROUND: The integration of artificial intelligence (AI) into health care is set to revolutionize the sector, offering opportunities to enhance diagnostic accuracy, personalize treatment, and improve patient outcomes. However, little is known abou...

DDX55 safeguards naïve T cell homeostasis by suppressing activation-promoting transposable elements.

Science immunology
Naïve T cells are maintained in a homeostatic state to preserve a stable T cell pool with diverse T cell receptor (TCR) repertoires, ensuring preparedness for priming. However, the underlying mechanisms controlling naïve T cell homeostasis and primin...

AI-powered automated model construction for patient-specific CFD simulations of aortic flows.

Science advances
Image-based modeling is essential for understanding cardiovascular hemodynamics and advancing the diagnosis and treatment of cardiovascular diseases. Constructing patient-specific vascular models remains labor-intensive, error-prone, and time-consumi...

Robotic micromanipulation for patterned and complex organoid biofabrication.

Science advances
Organoids have emerged as powerful models for recapitulating tissue physiology and pathology in biomedical research. However, the need for consistent and complex manufacturing of organoids remains a challenge. The absence of standardization and quali...