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End-to-End syndrome differentiation of Yin deficiency and Yang deficiency in traditional Chinese medicine.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Yin and Yang, two concepts adapted from classical Chinese philosophy, play a diagnostic role in Traditional Chinese Medicine (TCM). The Yin and Yang in harmonious balance indicate health, whereas imbalances to either side in...

Using Kalman Filtering to Forecast Disease Trajectory for Patients With Normal Tension Glaucoma.

American journal of ophthalmology
PURPOSE: To determine whether a machine learning technique called Kalman filtering (KF) can accurately forecast future values of mean deviation (MD), pattern standard deviation, and intraocular pressure for patients with normal tension glaucoma (NTG)...

Prediction of clinically relevant drug-induced liver injury from structure using machine learning.

Journal of applied toxicology : JAT
Drug-induced liver injury (DILI) is the most common cause of acute liver failure and often responsible for drug withdrawals from the market. Clinical manifestations vary, and toxicity may or may not appear dose-dependent. We present several machine-l...

A predictive model for high/low risk group according to oncotype DX recurrence score using machine learning.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
BACKGROUND: Oncotype DX(ODX) is a 21-gene breast cancer recurrence score(RS) assay that aids in decision-making for chemotherapy in early-stage hormone receptor-positive(HR+)breast cancer. We developed a prediction tool using machine learning for hig...

Unsupervised and real-time spike sorting chip for neural signal processing in hippocampal prosthesis.

Journal of neuroscience methods
BACKGROUND: Damage to the hippocampus will result in the loss of ability to form new long-term memories and cognitive disorders. At present, there is no effective medical treatment for this issue. Hippocampal cognitive prosthesis is proposed to repla...

Mammographic Breast Density Assessment Using Deep Learning: Clinical Implementation.

Radiology
Purpose To develop a deep learning (DL) algorithm to assess mammographic breast density. Materials and Methods In this retrospective study, a deep convolutional neural network was trained to assess Breast Imaging Reporting and Data System (BI-RADS) b...

Structure and Protein Interaction-Based Gene Ontology Annotations Reveal Likely Functions of Uncharacterized Proteins on Human Chromosome 17.

Journal of proteome research
Understanding the function of human proteins is essential to decipher the molecular mechanisms of human diseases and phenotypes. Of the 17 470 human protein coding genes in the neXtProt 2018-01-17 database with unequivocal protein existence evidence ...

CT image segmentation of bone for medical additive manufacturing using a convolutional neural network.

Computers in biology and medicine
BACKGROUND: The most tedious and time-consuming task in medical additive manufacturing (AM) is image segmentation. The aim of the present study was to develop and train a convolutional neural network (CNN) for bone segmentation in computed tomography...
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