Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
May 29, 2025
Immunoglobulin A nephropathy (IgAN) and idiopathic membranous nephropathy (IMN) are the most prevalent primary glomerulonephritis (PGN) subtypes and can lead to end-stage renal disease. Conventional diagnostic methods in certain aspects are often lim...
Journal of chemical information and modeling
May 29, 2025
The self-aggregation of amyloid-β (Aβ) into fibrils is a hallmark of Alzheimer's disease (AD). Inhibition of Aβ aggregation with small molecule compounds represents a promising therapeutic strategy for AD. However, designing effective ligands is chal...
Journal of chemical information and modeling
May 29, 2025
AlphaFold2 and other deep learning tools represent the state of the art for protein structure prediction; however, they are still limited in their ability to model multiple protein conformations. Since the function of many proteins depends on their a...
Bacterial sepsis remains a leading cause of death globally, exacerbated by the rise of multidrug resistance (MDR). Host-directed therapy (HDT) has emerged as a promising nonantibiotic approach to combat infections; thus, multiple HDT targets have bee...
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
May 29, 2025
The integration and utilization of digital media, gamified learning strategies, and artificial intelligence (AI) are fundamentally transforming the landscape of oncology education and learning. These technologies collectively enhance knowledge dissem...
Reliable prediction of pathogenic variants plays a crucial role in personalized medicine, which aims to provide accurate diagnosis and individualized treatment using genomic medicine. This study introduces PRP, a pathogenic risk prediction for rare n...
International journal of molecular sciences
May 29, 2025
Coronary artery disease (CAD) remains a major cause of cardiovascular morbidity and mortality, with growing evidence linking immune dysregulation to its pathogenesis. Aortic stenosis often coexists with CAD (ASCAD), representing an advanced disease f...
BACKGROUND: The global malaria burden is characterized by economic, geographical, and climatic disparities, especially in sub-Saharan Africa (SSA). Moreover, meteorological factors have become increasingly important to understand the malaria burden i...
INTRODUCTION: Technological advances and artificial intelligence now make it feasible to administer cognitive assessments on touch-screen devices. The aim of this study is to develop a Uyghur version of the NUCOG cognitive screening application and e...
BACKGROUND: Environmental factors have been identified as significant risk factors for scrub typhus. However, the impact of inorganic compounds such as greenhouse gases and air pollutants on the incidence of scrub typhus has not been evaluated.
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