AIMC Topic: Humans

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Establishment of a prognostic model based on ER stress-related cell death genes and proposing a novel combination therapy in acute myeloid leukemia.

Journal of translational medicine
BACKGROUND: Acute myeloid leukemia (AML) is a highly heterogeneous malignancy, presenting significant challenges in accurately predicting patient prognosis. Dysregulation of endoplasmic reticulum (ER) stress and resistance to programmed cell death (P...

Association between atherogenicity indices and prediabetes: a 5-year retrospective cohort study in a general Chinese physical examination population.

Cardiovascular diabetology
BACKGROUND AND OBJECTIVE: Atherogenicity indices have emerged as promising markers for cardiometabolic disorders, yet their relationship with prediabetes risk remains unclear. This study aimed to comprehensively evaluate the associations between six ...

Development of a risk prediction model for secondary infection in severe/critical COVID-19 patients.

BMC infectious diseases
OBJECTIVE: This study aimed to develop a predictive model for secondary infections in patients with severe or critical COVID-19 by analyzing clinical characteristics and laboratory indicators.

Customized GPT-4V(ision) for radiographic diagnosis: can large language model detect supernumerary teeth?

BMC oral health
BACKGROUND: With the growing capabilities of language models like ChatGPT to process text and images, this study evaluated their accuracy in detecting supernumerary teeth on periapical radiographs. A customized GPT-4V model (CGPT-4V) was also develop...

RNAcare: integrating clinical data with transcriptomic evidence using rheumatoid arthritis as a case study.

BMC medical genomics
BACKGROUND: Gene expression analysis is a crucial tool for uncovering the biological mechanisms that underlie differences between patient subgroups, offering insights that can inform clinical decisions. However, despite its potential, gene expression...

Synthesizing [F]PSMA-1007 PET bone images from CT images with GAN for early detection of prostate cancer bone metastases: a pilot validation study.

BMC cancer
BACKGROUND: [F]FDG PET/CT scan combined with [F]PSMA-1007 PET/CT scan is commonly conducted for detecting bone metastases in prostate cancer (PCa). However, it is expensive and may expose patients to more radiation hazards. This study explores deep l...

Co-designing an online educational resource to help adolescents improve their digital health literacy.

BMC public health
BACKGROUND: Digital media is ubiquitous in adolescents' lives and provides many opportunities to engage with health information. However, there is an increased risk of engaging with inaccurate or biased health information on the internet, resulting i...

Metabolic signature of COVID-19 progression: potential prognostic markers for severity and outcome.

Metabolomics : Official journal of the Metabolomic Society
INTRODUCTION: There are significant challenges remain in accurately categorizing the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients.

Imbalanced feature generation based on bootstrap power spectral curve for estimating respiratory rate.

Scientific reports
Rapid respiratory rate (RR) changes in older adults may indicate serious illness. Therefore, accurately estimating RR for cardiorespiratory fitness is essential. However, machine learning algorithm-related errors are unsuitable for medical decision-m...

Cultural differences in the beauty premium.

Scientific reports
A large body of research suggests that better-looking people are associated with various positive outcomes, an effect labeled the beauty premium. However, the vast majority of this evidence has been demonstrated in WEIRD (Western, Educated, Industria...