AIMC Topic: Hydrocortisone
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Separating generalized anxiety disorder from major depression using clinical, hormonal, and structural MRI data: A multimodal machine learning study.
Brain and behavior
Feb 12, 2017
BACKGROUND: Generalized anxiety disorder (GAD) is difficult to recognize and hard to separate from major depression (MD) in clinical settings. Biomarkers might support diagnostic decisions. This study used machine learning on multimodal biobehavioral...
Prenatal Stress Exposure Generates Higher Early Survival and Smaller Size without Impacting Developmental Rate in a Pacific Salmon.
Journal of experimental zoology. Part A, Ecological genetics and physiology
Jan 18, 2017
Prenatal exposure to elevated glucocorticoids can act as a signal of environmental stress, resulting in modifications to offspring phenotype. While "negative" phenotypic effects (i.e., smaller size, slower growth) are often reported, recent research ...
Support vector regression to estimate the permeability enhancement of potential transdermal enhancers.
The Journal of pharmacy and pharmacology
Jan 11, 2016
OBJECTIVES: Searching for chemicals that will safely enhance transdermal drug delivery is a significant challenge. This study applies support vector regression (SVR) for the first time to estimating the optimal formulation design of transdermal hydro...
Steroids Improve Hemodynamics in Infants With Adrenal Insufficiency After Cardiac Surgery.
Journal of cardiothoracic and vascular anesthesia
Nov 27, 2015
OBJECTIVE: To investigate whether steroid replacement therapy improved hemodynamics in infants after surgery for congenital heart disease only when they develop adrenal insufficiency. The authors retrospectively investigated adrenal function and eval...
Classifying Stress From Heart Rate Variability Using Salivary Biomarkers as Reference.
IEEE transactions on neural networks and learning systems
Sep 1, 2015
An accurate and noninvasive stress assessment from human physiology is a strenuous task. In this paper, a pattern recognition system to learn complex correlates between heart rate variability (HRV) features and salivary stress biomarkers is proposed....
Decoding chronic stress: From behavioral-molecular dynamics in mice to clinical implications of cortisol and IL-17 in depression severity.
Journal of affective disorders
Sep 15, 2025
BACKGROUNDS: The etiology of depression involves chronic stress, a recognized determinant of onset and severity. This study adopts a translational approach, utilizing a mouse model and a clinical cohort to explore the relationship between chronic str...
Using Machine Learning to Identify Predictors of Maternal and Infant Hair Cortisol Concentration Before and During the COVID-19 Pandemic.
Stress and health : journal of the International Society for the Investigation of Stress
Jun 1, 2025
Hair cortisol concentration (HCC) has been theorized to reflect chronic stress, and maternal and infant HCC may be correlated due to shared genetic, physiological, behavioural, and environmental factors, such as stressful life circumstances. The curr...
LC-MS/MS-Based Assay for Steroid Profiling in Peripheral and Adrenal Venous Samples for the Subtyping of Primary Aldosteronism.
Journal of clinical hypertension (Greenwich, Conn.)
May 1, 2025
Given the largely unexplored application of liquid chromatography-tandem mass spectrometry (LC-MS/MS) steroid analysis in primary aldosteronism (PA), we aimed to investigate its diagnostic utility in PA classification and to characterize steroid secr...
Utilizing dehydroepiandrosterone sulfate and its ratio for detecting mild autonomous cortisol excess in patients with adrenal incidentaloma.
Journal of medicine and life
Oct 1, 2023
Subclinical Cushing syndrome is a condition of mild autonomous cortisol excess (MACE) that lacks typical features of Cushing syndrome but is associated with many complications. It represents a common hormonal dysfunction among patients with adrenal i...
[Diagnostic value of urinary free cortisol in the subclinical Cushing's syndrome in patients with adrenal incidentaloma].
Zhonghua yi xue za zhi
Dec 12, 2017
To evaluate the efficacy of 24 h urinary free cortisol (24 h UFC) in the diagnosis of subclinical Cushing's syndrome (SCS), and explore the best diagnostic cut-off value. The clinical data of patients with adrenal incidentaloma in Chinese PLA Gener...
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