AIMC Topic: Immune Checkpoint Inhibitors
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Exploring machine learning tools in a retrospective case-study of patients with metastatic non-small cell lung cancer treated with first-line immunotherapy: A feasibility single-centre experience.
Lung cancer (Amsterdam, Netherlands)
Dec 31, 2024
BACKGROUND: Artificial intelligence (AI) models are emerging as promising tools to identify predictive features among data coming from health records. Their application in clinical routine is still challenging, due to technical limits and to explaina...
Deep learning on CT scans to predict checkpoint inhibitor treatment outcomes in advanced melanoma.
Scientific reports
Dec 30, 2024
Immune checkpoint inhibitor (ICI) treatment has proven successful for advanced melanoma, but is associated with potentially severe toxicity and high costs. Accurate biomarkers for response are lacking. The present work is the first to investigate the...
Integrating immune multi-omics and machine learning to improve prognosis, immune landscape, and sensitivity to first- and second-line treatments for head and neck squamous cell carcinoma.
Scientific reports
Dec 28, 2024
In recent years, immune checkpoint inhibitors (ICIs) has emerged as a fundamental component of the standard treatment regimen for patients with head and neck squamous cell carcinoma (HNSCC). However, accurately predicting the treatment effectiveness ...
Optimizing the management of immune-related adverse events and survival in patients with thoracic cancer receiving immunotherapy through artificial intelligence (electronic patient-reported outcomes): The IMPATHI study.
Bulletin du cancer
Dec 18, 2024
INTRODUCTION: The lung cancer continues to be the primary cause of cancer-related deaths, despite significant advancements in treatment through the introduction of immunological checkpoint inhibitors (ICI). These inhibitors, initially used as monothe...
Real-World and Clinical Trial Validation of a Deep Learning Radiomic Biomarker for PD-(L)1 Immune Checkpoint Inhibitor Response in Advanced Non-Small Cell Lung Cancer.
JCO clinical cancer informatics
Dec 13, 2024
PURPOSE: This study developed and validated a novel deep learning radiomic biomarker to estimate response to immune checkpoint inhibitor (ICI) therapy in advanced non-small cell lung cancer (NSCLC) using real-world data (RWD) and clinical trial data.
Multi-omics analysis and experiments uncover the function of cancer stemness in ovarian cancer and establish a machine learning-based model for predicting immunotherapy responses.
Frontiers in immunology
Dec 11, 2024
BACKGROUND: The heterogeneity of cancer makes it challenging to predict its response to immunotherapy, highlighting the need to find reliable biomarkers for assessment. The sophisticated role of cancer stemness in mediating resistance to immune check...
Integrating necroptosis into pan-cancer immunotherapy: a new era of personalized treatment.
Frontiers in immunology
Dec 9, 2024
INTRODUCTION: Necroptosis has emerged as a promising biomarker for predicting immunotherapy responses across various cancer types. Its role in modulating immune activation and therapeutic outcomes offers potential for precision oncology.
Deep learning-assisted colonoscopy images for prediction of mismatch repair deficiency in colorectal cancer.
Surgical endoscopy
Dec 2, 2024
BACKGROUND: Deficient mismatch repair or microsatellite instability is a major predictive biomarker for the efficacy of immune checkpoint inhibitors of colorectal cancer. However, routine testing has not been uniformly implemented due to cost and res...
The role of artificial intelligence in immune checkpoint inhibitor research: A bibliometric analysis.
Human vaccines & immunotherapeutics
Nov 28, 2024
Immune checkpoint inhibitors (ICIs) are revolutionizing cancer treatment, and Artificial Intelligence (AI) is a key player in this field. A comprehensive analysis of AI's impact on these inhibitors was lacking, but this study addresses that by analyz...
A comprehensive neuroimaging review of the primary and metastatic brain tumors treated with immunotherapy: current status, and the application of advanced imaging approaches and artificial intelligence.
Frontiers in immunology
Nov 28, 2024
Cancer immunotherapy has emerged as a novel clinical therapeutic option for a variety of solid tumors over the past decades. The application of immunotherapy in primary and metastatic brain tumors continues to grow despite limitations due to the phys...
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