Exosomal long noncoding RNAs (lncRNA) have significant potential as a biomarker for early cancer diagnosis. Accurate and sensitive detection of this abnormal expression remains challenging. Herein, we develop an innovative dual-mode photoelectrochemi...
BACKGROUND: Brain parenchymal tuberculoma (BT) and brain metastases (BM) originating from lung cancer often exhibit overlapping clinical and imaging features, making accurate differentiation challenging. Current diagnostic approaches remain suboptima...
The epidermal growth factor receptor (EGFR) is a key regulator of cell proliferation and a well-established therapeutic target in non-small-cell lung cancer (NSCLC). Somatic mutations in the EGFR gene have been widely studied in the context of tyrosi...
Early detection of lung cancer is crucial for improving patient outcomes. However, accurately diagnosing invasive pulmonary nodules and predicting tumor invasiveness remain major clinical challenges. Given the established role of immune dysfunction i...
Lung cancer remains a significant cause of mortality, with non-small cell lung cancer (NSCLC) representing most cases. Currently, clinical data based models fall short in predicting survival while more advanced deep learning based image models requir...
Biomedical physics & engineering express
Dec 3, 2025
Lung cancer remains one of the deadliest forms of cancer worldwide, making early and accurate pulmonary-nodule classification essential for improving patient prognosis. This study presents a robust ensemble-stacking framework that integrates Histogra...
Early detection of lung adenocarcinoma (LUAD) remains a major clinical challenge despite the widespread application of low-dose computed tomography (LDCT). Circulating PIWI-interacting RNAs (piRNAs), characterized by tumor-specific expression and hig...
BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the most prevalent malignancies and currently shows a poor clinical prognosis. Type II pneumocyte, as one of the main sources of cancer cells in NSCLC, is important to explore the molecular fun...
To develop and validate a machine learning (ML) model for predicting early recurrence (ER) within two years post-surgery in non-small cell lung cancer (NSCLC) patients. This multicenter cohort study included 3,171 NSCLC patients who underwent radical...
BACKGROUND: Lung adenocarcinoma (LUAC) patients with micropapillary (MP) and/or solid (S) generally demonstrate a poorer survival prognosis. In the diagnosis and treatment of stage IA LUAC, precisely establishing personalized treatment strategies for...
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